National Centre for Biological Science, Tata Institute for Fundamental Research, Bangalore 560065, India; email:
Institute for Stem Cell Science and Regenerative Medicine, Bangalore, 560065, India.
Annu Rev Cell Dev Biol. 2019 Oct 6;35:55-84. doi: 10.1146/annurev-cellbio-100617-062710. Epub 2019 Jul 5.
Endocytosis has long been identified as a key cellular process involved in bringing in nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in maintaining cell membrane compositional homeostasis. While clathrin-mediated endocytosis has been most extensively studied, a number of clathrin-independent endocytic pathways are continuing to be delineated. Here we provide a current survey of the different types of endocytic pathways available at the cell surface and discuss a new classification and plausible molecular mechanisms for some of the less characterized pathways. Along with an evolutionary perspective of the origins of some of these pathways, we provide an appreciation of the distinct roles that these pathways play in various aspects of cellular physiology, including the control of signaling and membrane tension.
胞吞作用长期以来一直被认为是一种关键的细胞过程，参与摄取营养物质、清除组织中的细胞碎片、调节信号转导以及维持细胞膜组成的动态平衡。虽然网格蛋白介导的胞吞作用已得到广泛研究，但许多非网格蛋白依赖的胞吞途径仍在不断被描绘。在这里，我们提供了目前对细胞表面可用的不同类型胞吞途径的调查，并讨论了一些较少被描述的途径的新分类和可能的分子机制。结合对这些途径中一些途径起源的进化视角，我们赞赏了这些途径在细胞生理学的各个方面，包括信号控制和膜张力，中发挥的独特作用。
