5-羟色氨酸对正常受试者及情感障碍患者H反射恢复曲线的影响。
Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders.
作者信息
Metz J T, Holcomb H H, Meltzer H Y
机构信息
Department of Psychiatry, University of Chicago, IL.
出版信息
Biol Psychiatry. 1988 Mar 15;23(6):602-11. doi: 10.1016/0006-3223(88)90007-8.
The effect of the serotonin precursor DL-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.
在正常受试者和情感性疾病患者中研究了血清素前体DL-5-羟色氨酸（5-HTP）对霍夫曼反射恢复曲线（HRRC）的影响。5-HTP可显著降低正常对照组以及接受锂盐或抗抑郁药治疗的抑郁和躁狂患者的HRRC。5-HTP可增加未接受药物治疗的抑郁和躁狂患者的HRRC。这些结果为情感障碍中血清素能异常提供了进一步的证据。
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