Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Int J Mol Sci. 2019 Jul 5;20(13):3319. doi: 10.3390/ijms20133319.
Numerous studies have examined the genetic association of vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) with recurrent pregnancy loss (RPL). However, of the four known SNPs in the 3'-untranslated region (3'-UTR) of , three SNPs-namely rs3025040 (1451C>T), rs10434 (1612G>A), and rs3025053 (1725G>A)-remain poorly characterized with regard to RPL. Herein, we evaluated the association between these three SNPs in the 3'-UTR and RPL susceptibility. We analyzed 3'-UTR gene variants in with and without RPL using TaqMan allelic discrimination. There were significant differences in the genotype frequencies of 1612G>A (GA: adjusted odds ratio (AOR), 0.652; 95% confidence interval (CI), 0.447-0.951; = 0.026) and 1725G>A (GA: AOR, 0.503; 95% CI, 0.229-0.848; = 0.010) in RPL patients vs. controls. Our results indicate that the 1612G>A and 1725G>A polymorphisms in the 3'-UTR of are associated with RPL susceptibility in Korean women. These data suggest that 3'-UTR polymorphisms may be utilized as biomarkers for the detection of RPL risk and prevention.
大量研究探讨了血管内皮生长因子 (VEGF) 单核苷酸多态性 (SNP) 与复发性妊娠丢失 (RPL) 的遗传关联。然而，在 3'非翻译区 (3'UTR) 中已知的四个 SNP 中，三个 SNP-即 rs3025040(1451C>T)、rs10434(1612G>A)和 rs3025053(1725G>A)-与 RPL 相关性仍描述不足。在此，我们评估了这三个 SNP 与 RPL 易感性之间的关联。我们使用 TaqMan 等位基因鉴别分析了 RPL 患者和对照组中 3'UTR 基因变异。在 RPL 患者中，1612G>A(GA:调整后的优势比(AOR)，0.652；95%置信区间(CI)，0.447-0.951； = 0.026)和 1725G>A(GA:AOR，0.503；95%CI，0.229-0.848； = 0.010)的基因型频率存在显著差异。我们的结果表明，VEGF 3'UTR 中的 1612G>A 和 1725G>A 多态性与韩国女性的 RPL 易感性相关。这些数据表明，3'UTR 多态性可作为检测 RPL 风险和预防的生物标志物。
