血管内皮生长因子基因多态性与复发性自然流产风险的关联：一项系统评价和荟萃分析。
Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis.
作者信息
Xu Xinghua, Du Chigang, Li Huihui, Du Jing, Yan Xue, Peng Lina, Li Guangyao, Chen Zi-Jiang
机构信息
Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China; Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China.
Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, 252000, China.
出版信息
PLoS One. 2015 Apr 20;10(4):e0123696. doi: 10.1371/journal.pone.0123696. eCollection 2015.
BACKGROUND
Studies of the associations between the genetic polymorphisms of the vascular endothelial growth factor (VEGF) gene and recurrent spontaneous abortion (RSA) have revealed conflicting results. The present meta-analysis was performed to provide a more precise estimation of these relationships and to explore potential sources of heterogeneity that may have influenced the reported disparities.
METHODS
An extensive literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library through June 6, 2014. Crude odds ratio (OR) with 95% confidence intervals were calculated.
RESULTS
10 case-control studies including 1,832 RSA patients and 2,271 healthy controls were identified. Meta-analysis indicated that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms in the VEGF gene correlated with elevated RSA risk. The rs1570360 variant was statistically significantly relevant to RSA risk among non-Asian populations. Interestingly, the rs3025039 variant was statistically significantly relevant to RSA risk among Asian populations.
CONCLUSIONS
The current meta-analysis indicates that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms increase RSA susceptibility. Moreover, rs1570360 and rs3025039 polymorphisms may play various roles in RSA susceptibility in various geographic groups.
背景
血管内皮生长因子（VEGF）基因的基因多态性与复发性自然流产（RSA）之间关联的研究结果相互矛盾。进行本荟萃分析以更精确地估计这些关系，并探索可能影响所报道差异的潜在异质性来源。
方法
通过2014年6月6日在PubMed、Embase和Cochrane图书馆对相关研究进行广泛的文献检索。计算了粗比值比（OR）及其95%置信区间。
结果
确定了10项病例对照研究，包括1832例RSA患者和2271例健康对照。荟萃分析表明，VEGF基因中的rs1570360、rs3025039、rs2010963和rs3025020多态性与RSA风险升高相关。rs1570360变异在非亚洲人群中与RSA风险具有统计学显著相关性。有趣的是，rs3025039变异在亚洲人群中与RSA风险具有统计学显著相关性。
结论
当前的荟萃分析表明，rs1570360、rs3025039、rs2010963和rs3025020多态性增加了RSA易感性。此外，rs1570360和rs3025039多态性在不同地理群体的RSA易感性中可能发挥不同作用。
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