Galil K A, Setchell B P
ARC Institute of Animal Physiology, Cambridge, U.K.
Int J Androl. 1988 Feb;11(1):73-85. doi: 10.1111/j.1365-2605.1988.tb01218.x.
Exposure of one or both testes of rats to heating at 43 degrees C for 30 min resulted in a significant reduction in blood flow per testis, as measured using microspheres. The effects on the testes of unilateral and bilateral heating were similar, although the changes in FSH levels in peripheral blood were in general less marked after unilateral heating. Testicular blood flow fell, along with testicular weight, beginning at 2-4 days and reaching minimum values 14-21 days after heating. Both blood flow per testis and testicular weight were beginning to recover 35 days post-heating and blood flow per testis was normal by 56 days following heat treatment, although testicular weight was still slightly reduced at that time. Heating one or both testes to 42 degrees C produced similar but smaller responses 21 days later, whereas temperatures of 41 degrees C or lower were without effect on the parameters measured, except for some rises in serum LH and FSH. With slight reductions in blood flow, there were corresponding increases in testicular venous testosterone concentration so that testosterone secretion was unaffected. Further reductions in blood flow at 14 and 21 days after heating to 43 degrees C were not fully compensated by an increase in the concentration of testosterone in testicular venous blood, with the result that testosterone secretion fell.
将大鼠的一侧或双侧睾丸暴露于43摄氏度加热30分钟后，使用微球测量发现，每个睾丸的血流量显著减少。单侧和双侧加热对睾丸的影响相似，尽管单侧加热后外周血中促卵泡激素（FSH）水平的变化通常不太明显。睾丸血流量随着睾丸重量下降，在加热后2至4天开始，在14至21天达到最低值。每个睾丸的血流量和睾丸重量在加热后35天开始恢复，热处理后56天时每个睾丸的血流量恢复正常，尽管此时睾丸重量仍略有降低。将一侧或双侧睾丸加热至42摄氏度在21天后产生类似但较小的反应，而4l摄氏度或更低的温度对所测量的参数没有影响，血清促黄体生成素（LH）和FSH略有升高除外。随着血流量略有减少，睾丸静脉睾酮浓度相应增加，因此睾酮分泌不受影响。加热至43摄氏度后14天和21天时血流量进一步减少，睾丸静脉血中睾酮浓度的增加未能完全补偿，结果睾酮分泌下降。
