Kikuchi Y, Kizawa I, Oomori K, Iwano I, Kita T, Kato K
Department of Obstetrics and Gynecology, National Defense Medical College, Saitama.
Jpn J Cancer Res. 1988 Jan;79(1):125-30. doi: 10.1111/j.1349-7006.1988.tb00019.x.
The effects of PSK on OKT 4/OKT 8 cell ratio, interleukin-2 (IL-2) production and expression of IL-2 receptor were examined in peripheral blood lymphocytes (PBL) from patients with advanced ovarian cancer during the course of chemotherapy. Preoperative levels of OKT 4/OKT 8 cell ratio and IL-2 production in PBL from patients with advanced ovarian cancer were significantly lower than those in cases of benign ovarian tumor. However, the expression of IL-2 receptor did not show any significant difference between ovarian cancer and benign ovarian tumor patients. When a combination chemotherapy of cisplatin, adriamycin and cyclophosphamide was given, the OKT 4/OKT 8 cell ratio was significantly increased with a significant decrease of the absolute number of the OKT 8 cell subset, while the expression of IL-2 receptor and the absolute number of the OKT 4 cell subset remained unchanged. In contrast, the IL-2 production was markedly depressed after the first course of chemotherapy. When PSK was combined with combination chemotherapy, the degree of inhibition of IL-2 production was reduced (though the effect was not statistically significant). If treatment with PSK was initiated after completion of combination chemotherapy, in addition to a significant elevation of OKT 4/OKT 8 cell ratio the depressed IL-2 production was restored to benign control levels. On the other hand, the expression of IL-2 receptor remained unchanged even if PSK was given after completion of chemotherapy.
在晚期卵巢癌患者化疗过程中，研究了PSK对其外周血淋巴细胞（PBL）中OKT 4/OKT 8细胞比例、白细胞介素-2（IL-2）产生及IL-2受体表达的影响。晚期卵巢癌患者术前PBL中OKT 4/OKT 8细胞比例和IL-2产生水平显著低于良性卵巢肿瘤患者。然而，IL-2受体表达在卵巢癌患者和良性卵巢肿瘤患者之间未显示出任何显著差异。给予顺铂、阿霉素和环磷酰胺联合化疗时，OKT 4/OKT 8细胞比例显著升高，OKT 8细胞亚群绝对数量显著减少，而IL-2受体表达和OKT 4细胞亚群绝对数量保持不变。相反，在第一个化疗疗程后，IL-2产生明显受抑。当PSK与联合化疗联合应用时，IL-2产生的抑制程度降低（尽管效果无统计学意义）。如果在联合化疗完成后开始使用PSK治疗，除了OKT 4/OKT 8细胞比例显著升高外，受抑的IL-2产生恢复到良性对照水平。另一方面，即使在化疗完成后给予PSK，IL-2受体表达仍保持不变。
