Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Gyeongsang National University, School of Medicine, Changwon, Republic of Korea.
lnstitute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Eye (Lond). 2019 Dec;33(12):1930-1938. doi: 10.1038/s41433-019-0525-9. Epub 2019 Jul 8.
To investigate the effect of optic disc size on correlation between Bruch's membrane opening-minimum rim width (BMO-MRW) and peripapillary retinal nerve fibre layer (RNFL) thickness from three scan circles.
In this retrospective, observational study, non-glaucomatous eyes without visible RNFL defect or visual field loss were included. A total of 101 subjects were distributed into three groups based on disc size: group 1 (n = 26), small disc (disc area < 1.63 mm); group 2 (n = 40), regular size disc (disc area: 1.63~2.43 mm); and group 3 (n = 35), large disc (disc area > 2.43 mm). All patients underwent standard ophthalmic examinations including confocal scanning laser tomography and spectral-domain optical coherence tomography.
Global BMO-MRW was the thickest in group 1 (314.96 ± 60.38 μm, BMO area: 1.72 ± 0.45 mm), followed by that in group 2 (259.03 ± 40.04 μm, BMO area: 2.29 ± 0.31 mm). It was the thinnest in group 3 (236.74 ± 31.21 μm, BMO area: 2.91 ± 0.31 mm; p < 0.001, Kruskal-Wallis test). Correlation between global BMO-MRW value and RNFL thickness was the strongest in group 3 (Spearman's rho = 0.656), followed by that in group 2 (rho = 0.572). It was the weakest in group 1 (rho = 0.147). There was no significant difference in global RNFL thickness by disc size from either the 3.5 mm, 4.1 mm, or 4.7 mm diameter scan circles (all p > 0.05).
Correlation between BMO-MRW values and RNFL thickness differed significantly according to disc size. Thus, when we assess BMO-MRW in relation to RNFL thickness, disc size may need to be taken into consideration.
探讨视盘大小对三个扫描环的 Bruch 膜开口最小边缘宽度（BMO-MRW）与视盘周围视网膜神经纤维层（RNFL）厚度之间相关性的影响。
本回顾性观察性研究纳入了无可见 RNFL 缺损或视野丧失的非青光眼眼。根据视盘大小将 101 例受试者分为三组：第 1 组（n=26），小视盘（视盘面积<1.63mm）；第 2 组（n=40），正常大小视盘（视盘面积：1.63~2.43mm）；第 3 组（n=35），大视盘（视盘面积>2.43mm）。所有患者均接受标准眼科检查，包括共焦激光扫描断层成像术和频域光相干断层扫描。
第 1 组的全局 BMO-MRW 最厚（314.96±60.38μm，BMO 面积：1.72±0.45mm），其次是第 2 组（259.03±40.04μm，BMO 面积：2.29±0.31mm）。第 3 组最薄（236.74±31.21μm，BMO 面积：2.91±0.31mm；p<0.001，Kruskal-Wallis 检验）。第 3 组的全局 BMO-MRW 值与 RNFL 厚度之间的相关性最强（Spearman's rho=0.656），其次是第 2 组（rho=0.572）。第 1 组最弱（rho=0.147）。无论使用 3.5mm、4.1mm 还是 4.7mm 直径扫描环，视盘大小与全局 RNFL 厚度之间均无显著差异（均 p>0.05）。
BMO-MRW 值与 RNFL 厚度之间的相关性根据视盘大小而有显著差异。因此，当我们评估 BMO-MRW 与 RNFL 厚度的关系时，可能需要考虑视盘大小。
