1Neuroscience Graduate Program, Virginia Commonwealth University, Richmond, VA 23298 USA.
2Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 USA.
Commun Biol. 2019 Jul 3;2:252. doi: 10.1038/s42003-019-0492-5. eCollection 2019.
Although numerous studies have demonstrated that neuronal mechanisms regulate alcohol-related behaviors, very few have investigated the direct role of glia in behavioral responses to alcohol. The results described here begin to fill this gap in the alcohol behavior and gliobiology fields. Since exhibit conserved behavioral responses to alcohol and their CNS glia are similar to mammalian CNS glia, we used to begin exploring the role of glia in alcohol behavior. We found that knockdown of () in glia increased alcohol sedation and that this effect was specific to cortex glia and adulthood. These data implicate and cortex glia in alcohol-related behaviors. Cortex glia are functionally homologous to mammalian astrocytes and Cp1 is orthologous to mammalian Cathepsin L. Our studies raise the possibility that cathepsins may influence behavioral responses to alcohol in mammals via roles in astrocytes.
尽管有大量研究表明神经元机制调节与酒精相关的行为，但很少有研究调查神经胶质在酒精行为反应中的直接作用。这里描述的结果开始填补酒精行为学和神经胶质生物学领域的这一空白。由于 对酒精表现出保守的行为反应，并且它们的中枢神经系统神经胶质与哺乳动物的中枢神经系统神经胶质相似，因此我们使用 来开始探索神经胶质在酒精行为中的作用。我们发现，神经胶质中的 （）敲低增加了 的酒精镇静作用，并且这种作用特异性地存在于皮质神经胶质和成年期。这些数据表明 和皮质神经胶质参与了与酒精相关的行为。皮质神经胶质在功能上与哺乳动物的星形胶质细胞同源，而 Cp1 与哺乳动物的组织蛋白酶 L 同源。我们的研究提出了这样一种可能性，即组织蛋白酶可能通过在星形胶质细胞中的作用影响哺乳动物对酒精的行为反应。
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