Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Av. Hippocrate 10, 1200, Brussels, Belgium.
Department of Neurology, Center for Refractory Epilepsy, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Av. Hippocrate 10, 1200, Brussels, Belgium.
Acta Neurol Belg. 2019 Sep;119(3):315-324. doi: 10.1007/s13760-019-01185-5. Epub 2019 Jul 8.
Lennox-Gastaut syndrome (LGS) is a rare, age-related syndrome, characterized by multiple seizure types, mental regression, and specific EEG abnormalities. It is one of the most challenging epilepsy: treatment is rarely effective and the final prognosis remains poor, despite the availability of several antiepileptic drugs, validated through well-designed, randomized, controlled trials. However, it is reasonable to consider non-medical treatments, such as surgery, after failure of two-to-three drugs. This review has as goal to describe systematically the different therapeutic options for LGS, including, not only recognized antiepileptic drugs, but also new oral drugs, immune therapy, diet, surgery, and neurostimulation techniques.
Lennox-Gastaut 综合征（LGS）是一种罕见的、与年龄相关的综合征，其特征是多种癫痫发作类型、智力衰退和特定的脑电图异常。它是最具挑战性的癫痫之一：尽管有几种经过精心设计的随机对照试验验证的抗癫痫药物，但治疗效果很少有效，最终预后仍然很差。然而，在两种至三种药物治疗失败后，考虑非医学治疗（如手术）是合理的。本综述的目的是系统地描述 LGS 的不同治疗选择，包括不仅是公认的抗癫痫药物，还有新的口服药物、免疫疗法、饮食、手术和神经刺激技术。
