Ha Mei, Chen Jun, Zhang Xiaojuan, Yang Hong, Liu Changjiang
School of Nursing, Chongqing Medical and Pharmaceutical College, Chongqing, China.
Chenjiaqiao Hospital, the Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China.
Jpn J Nurs Sci. 2020 Jan;17(1):e12280. doi: 10.1111/jjns.12280. Epub 2019 Jul 8.
There is increasing evidence that hyperglycemia, oxidative stress, and the accumulation of advanced glycation end products in type 2 diabetes mellitus (T2DM) can lead to the deterioration of bone remodeling. The purpose of this study was to explore relationships of social support, health-promoting lifestyles, glycated hemoglobin (HbA1c) levels, and serum bone turnover markers (BTMs, including procollagen type I amino-terminal propeptide [PINP] and β-isomerised carboxy-terminal cross-linking telopeptide of type I collagen [β-CTX]) among individuals with T2DM.
A total of 175 subjects were recruited by convenience sampling and divided into three groups based on their HbA1c levels. Statistical strategies of Spearman's correlation coefficient and multiple linear regression were used in this cross-sectional study.
There was a positive association between PINP and β-CTX, whereas the HbA1c level was inversely correlated with BTMs. Moreover, scores of both PINP and β-CTX were different in genders, males having lower levels of BTMs than females after adjustment for weight. Furthermore, both social support and health-promoting lifestyles were negatively correlated with HbA1c levels, whereas they did not significantly relate to declines in PINP and β-CTX.
High HbA1c levels detrimentally influence bone formation and bone resorption, and males with T2DM might be more susceptible to osteoporosis because of their relatively lower levels of BTMs. However, social support and health-promoting lifestyles could contribute to better glycemic control.
越来越多的证据表明，2型糖尿病（T2DM）中的高血糖、氧化应激和晚期糖基化终产物的积累会导致骨重塑恶化。本研究的目的是探讨T2DM患者的社会支持、健康促进生活方式、糖化血红蛋白（HbA1c）水平和血清骨转换标志物（BTMs，包括I型前胶原氨基端前肽[PINP]和I型胶原β-异构化羧基末端交联端肽[β-CTX]）之间的关系。
通过便利抽样招募了175名受试者，并根据他们的HbA1c水平分为三组。在这项横断面研究中使用了Spearman相关系数和多元线性回归的统计方法。
PINP与β-CTX之间存在正相关，而HbA1c水平与BTMs呈负相关。此外，PINP和β-CTX的得分在性别上存在差异，在调整体重后，男性的BTMs水平低于女性。此外，社会支持和健康促进生活方式均与HbA1c水平呈负相关，而它们与PINP和β-CTX的下降无显著相关性。
高HbA1c水平对骨形成和骨吸收有不利影响，T2DM男性可能因其相对较低的BTMs水平而更容易患骨质疏松症。然而，社会支持和健康促进生活方式有助于更好地控制血糖。
