Wu Jia-Man, Chen Yan, Ning Yan, Chen Yu, Liao Jian, Zhuo Yuan-Yuan
Shenzhen Maternal and Child Health Care Hospital, Shenzhen 518028, Guangdong Province, China.
Department of Acupuncture and Moxibustion, Shenzhen TCM Hospital, Shenzhen 518033, Guangdong Province.
Zhongguo Zhen Jiu. 2019 Jul 12;39(7):689-93. doi: 10.13703/j.0255-2930.2019.07.002.
To observe the effects of acupoint catgut embedding on miscarriage prevention and pregnancy outcome in patients with threatened abortion after in vitro fertilization-embryo transfer (IVF-ET).
Sixty cases of patients with threatened abortion after IVF-ET were randomly divided into an observation group and a control group, 30 cases in each group. The patients in the control group were treated with intramuscular injection of progesterone (40 mg) once every day, while the patients in the observation group, on the basis of the treatment of control group, were treated with catgut embedding at Geshu (BL 17), Ganshu (BL 18), Shenshu (BL 23), Pishu (BL 20), Weishu (BL 21), Xuehai (SP 10), Diji (SP 8) and Fuliu (KI 7), once every two weeks, six times as a course of treatment. The treatment was given until 12 weeks into pregnancy. The level of serum human chorionic gonadotropin (HCG), estradiol (E) and progesterone (P) before and after treatment was recorded; the TCM syndrome score before and after treatment was compared; the successful pregnancy rate and spontaneous abortion rate after treatment were observed in the two groups.
Compared before treatment, the scores of TCM syndrome in both groups were reduced after treatment (both <0.01), and score in the observation group was superior to that in the control group (<0.05). After treatment, the clinical efficacy in the observation group was superior to that in the control group (<0.05). After treatment, the hormone levels (β-HCG, E, P) in both groups were increased steadily; the hormone levels in 6-week pregnancy, 8-week pregnancy and 10-week pregnancy were significantly higher than those in 4-week pregnancy (all <0.05); except the levels of P and β-HCG in 10-week pregnancy, the hormone levels in the observation group were superior to those in the control group (all <0.05). After treatment, the early abortion rate was 16.7% (5/30) in the observation group, which was lower than 33.3% (10/30) in the control group (<0.01); the pregnancy rate was 96.0% (24/25) in the observation group, which was higher than 80.0% (16/20) in the control group (<0.01).
Acupoint catgut embedding is effective for preventing threatened abortion, which could significantly reduce the spontaneous abortion rate, improve the pregnancy success rate, regulate hormone levels in patients after IVF-ET.
观察穴位埋线对体外受精-胚胎移植（IVF-ET）后先兆流产患者预防流产及妊娠结局的影响。
将60例IVF-ET后先兆流产患者随机分为观察组和对照组，每组30例。对照组患者每日肌内注射黄体酮（40mg），观察组患者在对照组治疗基础上，于膈俞（BL 17）、肝俞（BL 18）、肾俞（BL 23）、脾俞（BL 20）、胃俞（BL 21）、血海（SP 10）、地机（SP 8）、复溜（KI 7）穴位埋线，每两周1次，6次为1个疗程。治疗至妊娠12周。记录治疗前后血清人绒毛膜促性腺激素（HCG）、雌二醇（E）和孕酮（P）水平；比较治疗前后中医证候积分；观察两组治疗后的妊娠成功率和自然流产率。
与治疗前比较，两组治疗后中医证候积分均降低（均P<0.01），且观察组低于对照组（P<0.05）。治疗后，观察组临床疗效优于对照组（P<0.05）。治疗后，两组激素水平（β-HCG、E、P）均稳步升高；妊娠6周、8周、10周时激素水平均显著高于妊娠4周时（均P<0.05）；除妊娠10周时P和β-HCG水平外，观察组激素水平均优于对照组（均P<0.05）。治疗后，观察组早期流产率为16.7%（5/30），低于对照组的33.3%（10/30）（P<0.01）；观察组妊娠率为96.0%（24/25），高于对照组的80.0%（16/20）（P<0.01）。
穴位埋线对预防IVF-ET后先兆流产有效，可显著降低自然流产率，提高妊娠成功率，调节患者激素水平。
