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约旦大学医院胎儿心脏病的产前检测:一个发展中国家的早期经验

Prenatal detection of fetal heart disease at Jordan University Hospital: early experience in a developing country.

作者信息

Tutunji Laila, Thekrallah Fida, Basha Asma, Awaysheh Bushra, Amer Shorouq, Khatib Lina, Hamdan Lubna, Saber Nisreen, Mustafa Asma, Jadallah Rama, Kazaleh Fawaz, Al-Lawama Manar, Badran Eman, Al-Ammouri Iyad

机构信息

Section of Cardiology, Department of Pediatrics, Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Jordan, Amman-Jordan, Amman, 11942, Jordan.

出版信息

Cardiol Young. 2019 Aug;29(8):1072-1077. doi: 10.1017/S1047951119001550. Epub 2019 Jul 9.

Abstract

OBJECTIVE

To report on the first 5 years of establishment of fetal echocardiographic services at the Jordan University Hospital with emphasis on diagnosis and outcome.

METHODS

A retrospective chart review was conducted on all fetal echocardiographic studies performed between January 2011 and December 2015. Data collected included maternal demographics, referral indications, fetal cardiac diagnosis, correlation to post-natal diagnosis, outcome of pregnancy including pre-mature delivery and perinatal mortality. Basic statistical analysis was performed including demographic analysis, and calculation of fetal echocardiographic sensitivity and specificity.

RESULTS

A total of 208 fetuses underwent fetal echocardiographic evaluation at a mean gestational age of 26.5 (±5) weeks. The most common referral indication was a suspicion of CHD during the obstetric ultrasound (44.2%), followed by cardiac dysfunction (18.2%), and a family history of CHD (14.9%). Fetal echocardiography showed CHD in 71 fetuses (34%), heart failure in 26 (12.5%), arrhythmia in 9 (4.3%), and intracardiac masses in 2. In the remaining 100 fetuses (48%), fetal echocardiography showed normal evaluation. For detecting CHD, fetal echocardiography had a sensitivity and specificity of 91.7% and 95.4%, respectively. Perinatal mortality including termination of pregnancy, intrauterine fetal death, and neonatal mortality was highest in heart failure (77%), and was 41% for CHD.

CONCLUSION

The fetal cardiac diagnostic services at the Jordan University Hospital have encouraging initial results with a relatively high sensitivity and specificity. The services further positively impacted the quality of counselling offered and facilitated pre- and post-natal management.

摘要

目的

报告约旦大学医院胎儿超声心动图服务开展的前5年情况,重点关注诊断及结果。

方法

对2011年1月至2015年12月期间进行的所有胎儿超声心动图检查进行回顾性病历审查。收集的数据包括母亲人口统计学资料、转诊指征、胎儿心脏诊断、与产后诊断的相关性、妊娠结局,包括早产和围产期死亡率。进行了基本的统计分析,包括人口统计学分析,以及胎儿超声心动图敏感性和特异性的计算。

结果

共有208例胎儿接受了胎儿超声心动图评估,平均孕周为26.5(±5)周。最常见的转诊指征是产科超声检查时怀疑患有先天性心脏病(44.2%),其次是心脏功能障碍(18.2%)和先天性心脏病家族史(14.9%)。胎儿超声心动图显示71例胎儿患有先天性心脏病(34%),26例患有心力衰竭(12.5%),9例患有心律失常(4.3%),2例患有心内肿块。在其余100例胎儿(48%)中,胎儿超声心动图显示评估正常。对于检测先天性心脏病,胎儿超声心动图的敏感性和特异性分别为91.7%和95.4%。围产期死亡率,包括妊娠终止、宫内胎儿死亡和新生儿死亡在心衰中最高(77%),先天性心脏病为41%。

结论

约旦大学医院的胎儿心脏诊断服务取得了令人鼓舞的初步成果,具有相对较高的敏感性和特异性。这些服务进一步对所提供的咨询质量产生了积极影响,并促进了产前和产后管理。

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