Chatterjee-Hasrouni S, Lala P K
J Exp Med. 1979 May 1;149(5):1238-53. doi: 10.1084/jem.149.5.1238.
The presence of H-2 antigens of the paternal and maternal haplotypes on mouse trophoblast cells was examined at several stages of pregnancy by using a sensitive immunolabeling technique followed by quantitative radioautography. Results revealed the presence of H-2 antigens (determined by the K or D loci) of both parental haplotypes on the F1 trophoblast cells. At 14-16 d of gestation, the antigen density was equivalent to that on adult thymocytes and there was a further 50% increase on day 18. H-2 antigens of both parental haplotypes are also found to be expressed on 11-13 d trophoblast cells.
运用灵敏的免疫标记技术并结合定量放射自显影法,在妊娠的几个阶段检测了小鼠滋养层细胞上父本和母本单倍型的H-2抗原的存在情况。结果显示,F1滋养层细胞上存在双亲单倍型的H-2抗原(由K或D位点决定)。在妊娠14 - 16天时,抗原密度与成年胸腺细胞上的相当,且在第18天又进一步增加了50%。双亲单倍型的H-2抗原在妊娠11 - 13天的滋养层细胞上也有表达。