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H-2抗原在小鼠滋养层细胞上的定位

Localization of H-2 antigens on mouse trophoblast cells.

作者信息

Chatterjee-Hasrouni S, Lala P K

出版信息

J Exp Med. 1979 May 1;149(5):1238-53. doi: 10.1084/jem.149.5.1238.

Abstract

The presence of H-2 antigens of the paternal and maternal haplotypes on mouse trophoblast cells was examined at several stages of pregnancy by using a sensitive immunolabeling technique followed by quantitative radioautography. Results revealed the presence of H-2 antigens (determined by the K or D loci) of both parental haplotypes on the F1 trophoblast cells. At 14-16 d of gestation, the antigen density was equivalent to that on adult thymocytes and there was a further 50% increase on day 18. H-2 antigens of both parental haplotypes are also found to be expressed on 11-13 d trophoblast cells.

摘要

运用灵敏的免疫标记技术并结合定量放射自显影法,在妊娠的几个阶段检测了小鼠滋养层细胞上父本和母本单倍型的H-2抗原的存在情况。结果显示,F1滋养层细胞上存在双亲单倍型的H-2抗原(由K或D位点决定)。在妊娠14 - 16天时,抗原密度与成年胸腺细胞上的相当,且在第18天又进一步增加了50%。双亲单倍型的H-2抗原在妊娠11 - 13天的滋养层细胞上也有表达。

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引用本文的文献

本文引用的文献

1
Cytokinetic analysis of tumor growth.肿瘤生长的细胞动力学分析
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1735-42. doi: 10.1073/pnas.56.6.1735.
2
ANTIGEN BARRIER OF THE MOUSE PLACENTA.小鼠胎盘的抗原屏障
Nature. 1964 Nov 7;204:548-9. doi: 10.1038/204548a0.
4
The antigenicity of mouse trophoblast.小鼠滋养层细胞的抗原性。
Ann N Y Acad Sci. 1962 Oct 24;99:717-32. doi: 10.1111/j.1749-6632.1962.tb45356.x.
5
The immunological consequences of extrauterine development of allogeneic mouse blastocysts.
Transplantation. 1968 Dec;6(9):1005-9. doi: 10.1097/00007890-196812000-00007.
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The masking of antigens on trophoblast and cancer cells.
Lancet. 1967 Apr 1;1(7492):708-10. doi: 10.1016/s0140-6736(67)92183-6.

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