Musculoskeletal Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94107, USA.
Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany.
Skeletal Radiol. 2020 Feb;49(2):231-240. doi: 10.1007/s00256-019-03267-0. Epub 2019 Jul 9.
To compare the extent of cartilage deterioration in knees with prior meniscal resection related to trauma versus knees with resection related to degenerative disease, and to compare cartilage deterioration in knees with meniscal surgery to knees without meniscal surgery, controlling for prior knee trauma.
In this cross-sectional study, we assessed cartilage deterioration in right knees of Osteoarthritis Initiative participants: (i) with meniscal surgery due to injury (n = 79); (ii) matched control knees with a prior injury but without meniscal surgery (n = 79); (iii) with meniscal surgery but without preceding injury (n = 36); and (iv) matched control knees without meniscal surgery or prior knee injury (n = 36). Cartilage composition was measured using T2 measurements derived using semi-automatic cartilage segmentation of the right. Linear regression analysis was used to compare compartmental values of T2 between groups.
Comparing the mean T2 values in surgical cases with and without injury our results did not show significant differences (group i vs. iii, p > 0.05). However, knees with previous meniscal surgery showed significantly (p < 0.001) higher mean T2 values across all compartments (i.e., global T2) when compared to those without meniscal surgery for both knees with a history of trauma (group i vs. ii) and knees without prior trauma (group iii vs. iv). Similar results were obtained when analyzing the compartments separately.
Cartilage deterioration, assessed by T2, is similar in knees undergoing meniscal surgery after trauma and for degenerative conditions. Both groups demonstrated greater cartilage deterioration than nonsurgical knees, controlling for prior knee injury.
比较与创伤相关的半月板切除术和与退行性疾病相关的半月板切除术的膝关节软骨退变程度，并比较半月板手术和未行半月板手术的膝关节的软骨退变程度，同时控制既往膝关节创伤。
在这项横断面研究中，我们评估了 Osteoarthritis Initiative 参与者右膝关节的软骨退变情况：（i）因损伤而行半月板切除术（n=79）；（ii）有既往损伤但未行半月板切除术的配对对照膝关节（n=79）；（iii）有半月板切除术但无既往损伤的膝关节（n=36）；和（iv）无半月板切除术或既往膝关节损伤的配对对照膝关节（n=36）。使用右膝关节半自动软骨分割法测量 T2 测量值来评估软骨成分。使用线性回归分析比较组间 T2 分室值。
比较有损伤和无损伤手术病例的平均 T2 值，我们的结果显示两组之间无显著差异（组 i 与组 iii，p>0.05）。然而，与未行半月板切除术的膝关节相比，既往有半月板手术的膝关节在所有分室（即全局 T2）的平均 T2 值显著升高（p<0.001），包括有创伤史的膝关节（组 i 与组 ii）和无既往创伤史的膝关节（组 iii 与组 iv）。当分别分析分室时，也得到了类似的结果。
通过 T2 评估，在创伤后和退行性疾病相关的半月板切除术后膝关节的软骨退变程度相似。两组膝关节的软骨退变程度均大于未行手术的膝关节，同时控制了既往膝关节损伤。
