School of Medical Technology, Jiangsu Collge of Nursing, Huaian City, 223005, Jiangsu Province, China.
Department of Hepatobiliary Surgery, The Second Affiliation Hospital of Kunming Medical University, 243 Dianmian Avenue, Wuhua District, Kunming City, 650101, Yunnan Province, China.
Pathol Oncol Res. 2020 Apr;26(2):1301-1311. doi: 10.1007/s12253-019-00694-1. Epub 2019 Jul 9.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and occurs in people with chronic liver diseases. Current treatment methods include surgery, transplant, and chemotherapy. Our study demonstrates runt-related transcription factor 1 (RUNX1) as a novel molecule in the initiation and development of HCC, and the role of its interaction with vascular endothelial growth factor A (VEGFA) in HCC. We showed the suppressive role of RUNX1 in the proliferation and migration of hepatocytes. In addition, the repressor RUNX1 functioned as a transcription factor on the promoter of VEGFA to inhibit the expression of VEGFA. Study in the HCC cells demonstrated that the suppression of HCC proliferation and migration was masked in the presence of overexpressed VEGFA. Introduction of RUNX1 into HCC mice model significantly limited the tumor growth. In summary, our study demonstrated that RUNX1 functions as a repressor in the HCC and this suppressive function was dependent on its effect on VEGFA.
肝细胞癌 (HCC) 是最常见的原发性肝癌，发生于慢性肝病患者。目前的治疗方法包括手术、移植和化疗。我们的研究表明 runt 相关转录因子 1 (RUNX1) 是 HCC 发生和发展中的一种新分子，及其与血管内皮生长因子 A (VEGFA) 在 HCC 中的相互作用。我们展示了 RUNX1 在肝细胞增殖和迁移中的抑制作用。此外，抑制性 RUNX1 作为转录因子作用于 VEGFA 的启动子上，抑制 VEGFA 的表达。在 HCC 细胞中的研究表明，在过表达 VEGFA 的情况下，HCC 增殖和迁移的抑制作用被掩盖。将 RUNX1 导入 HCC 小鼠模型中，显著限制了肿瘤生长。总之，我们的研究表明，RUNX1 在 HCC 中作为一种抑制物发挥作用，这种抑制作用依赖于其对 VEGFA 的作用。
