Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Department of Psychiatry, Center for Weight and Eating Disorders, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Obes Surg. 2019 Dec;29(12):3941-3947. doi: 10.1007/s11695-019-04062-5.
Bariatric surgery is associated with improved cardiovascular outcomes and also affects lipid levels, but few studies have compared the effects of Roux-en-Y gastric bypass (RYGB) surgery with those of laparoscopic sleeve gastrectomy (LSG) on serum fatty acid levels. The present study compares the effects of RYGB and LSG surgeries on serum fatty acid levels.
The study participants were women who were undergoing either RYGB or LSG and body mass index (BMI)-matched controls. Fasting blood samples to measure glucose, insulin, and fatty acids were drawn at baseline and at 6 and 18 months from baseline.
Serum fatty acid data were available for 57 participants at baseline, of whom 56 had data at 6 months and 41 had data at 18 months from baseline. Compared with baseline, serum non-esterified fatty acids (NEFAs) levels were significantly higher at 6 and 18 months in the LSG group compared with the RYGB group. In the RYGB group, 2 saturated fatty acids (SFAs), 2 monounsaturated fatty acids (MUFAs), and 1 polyunsaturated fatty acid (PUFA) were significantly decreased after surgery, compared with those of the LSG group.
A significant increase in NEFAs was seen after LSG, compared with RYGB. Compared with the LSG group, several serum fatty acids were significantly reduced after RYGB.
NCT01228097.
减重手术可改善心血管结局，同时也影响血脂水平，但很少有研究比较胃旁路术（RYGB）与腹腔镜袖状胃切除术（LSG）对血清脂肪酸水平的影响。本研究比较了 RYGB 和 LSG 手术对血清脂肪酸水平的影响。
研究参与者为接受 RYGB 或 LSG 手术的女性，以及 BMI 匹配的对照组。基线时和基线后 6 个月和 18 个月抽取空腹血样，以测量血糖、胰岛素和脂肪酸。
57 名参与者在基线时有血清脂肪酸数据，其中 56 名在 6 个月时有数据，41 名在基线后 18 个月时有数据。与基线相比，LSG 组在 6 个月和 18 个月时血清非酯化脂肪酸（NEFAs）水平明显高于 RYGB 组。在 RYGB 组中，与 LSG 组相比，2 种饱和脂肪酸（SFAs）、2 种单不饱和脂肪酸（MUFAs）和 1 种多不饱和脂肪酸（PUFA）在手术后明显减少。
与 RYGB 相比，LSG 后 NEFAs 明显增加。与 LSG 组相比，RYGB 后几种血清脂肪酸明显减少。
NCT01228097。
