• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Therapeutic implications of advanced age at time of spinal cord injury.

作者信息

Stewart Andrew N, Gensel John C, Zhang Bei

机构信息

Spinal Cord and Brain Injury Research Center, Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA.

College of Public Health, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.

出版信息

Neural Regen Res. 2019 Nov;14(11):1895-1896. doi: 10.4103/1673-5374.259606.

DOI:10.4103/1673-5374.259606
PMID:31290439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6676888/
Abstract
摘要

相似文献

1
Therapeutic implications of advanced age at time of spinal cord injury.脊髓损伤时高龄的治疗意义。
Neural Regen Res. 2019 Nov;14(11):1895-1896. doi: 10.4103/1673-5374.259606.
2
The effect of trunk extension on physiological cost index in spinal cord injury patients when using the advanced reciprocating gait orthosis: A pilot study.使用先进往复式步态矫形器时躯干伸展对脊髓损伤患者生理成本指数的影响：一项初步研究。
Prosthet Orthot Int. 2016 Dec;40(6):696-702. doi: 10.1177/0309364615592700. Epub 2015 Jul 24.
3
Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury.神经元半胱天冬酶-1和-3在创伤性脊髓损伤小鼠模型中的功能作用及治疗意义
Neuroscience. 2000;99(2):333-42. doi: 10.1016/s0306-4522(00)00173-1.
4
The question of whether or not to perform therapeutic hypothermia: A case of neonatal spinal cord injury.是否进行治疗性低温的问题：一例新生儿脊髓损伤病例
J Neonatal Perinatal Med. 2017;10(2):195-198. doi: 10.3233/NPM-171695.
5
Late-life spinal cord injury and aging with a long term injury: characteristics of two emerging populations.
J Spinal Cord Med. 1995 Jul;18(3):183-93. doi: 10.1080/10790268.1995.11719391.
6
Furosemide Unmasks Inhibitory Dysfunction after Spinal Cord Injury in Humans: Implications for Spasticity.速尿揭示人类脊髓损伤后的抑制性功能障碍：对痉挛的影响。
J Neurotrauma. 2019 May 1;36(9):1469-1477. doi: 10.1089/neu.2017.5560. Epub 2018 Dec 19.
7
Shoulder biomechanics and muscle plasticity: implications in spinal cord injury.肩部生物力学与肌肉可塑性：对脊髓损伤的影响
Clin Orthop Relat Res. 2002 Oct(403 Suppl):S26-36. doi: 10.1097/00003086-200210001-00004.
8
Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications.脊髓损伤：病理生理学、治疗策略、相关挑战及未来影响。
Cell Tissue Res. 2019 Aug;377(2):125-151. doi: 10.1007/s00441-019-03039-1. Epub 2019 May 7.
9
Comparison of gait between healthy participants and persons with spinal cord injury when using the advanced reciprocating gait orthosis.使用先进往复式步态矫形器时健康参与者与脊髓损伤患者步态的比较。
Prosthet Orthot Int. 2016 Apr;40(2):287-93. doi: 10.1177/0309364615592699. Epub 2015 Jul 20.
10
The influence of trunk extension in using advanced reciprocating gait orthosis on walking in spinal cord injury patients: A pilot study.躯干伸展对脊髓损伤患者使用先进往复式步态矫形器行走的影响：一项初步研究。
Prosthet Orthot Int. 2015 Aug;39(4):286-92. doi: 10.1177/0309364614531010. Epub 2014 May 12.

引用本文的文献

1
Molecular pathology of acute spinal cord injury in middle-aged mice.中年小鼠急性脊髓损伤的分子病理学
J Neuroinflammation. 2025 Jul 13;22(1):181. doi: 10.1186/s12974-025-03494-4.
2
Molecular pathology of acute spinal cord injury in middle-aged mice.中年小鼠急性脊髓损伤的分子病理学
bioRxiv. 2025 May 14:2025.05.08.652873. doi: 10.1101/2025.05.08.652873.
3
Contrast-enhanced ultrasound imaging detects anatomical and functional changes in rat cervical spine microvasculature with normal aging.超声造影成像可检测正常衰老大鼠颈椎微血管的解剖和功能变化。

本文引用的文献

1
Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury.降低年龄相关的单核细胞衍生的巨噬细胞激活有助于 NADPH 氧化酶抑制在脊髓损伤中的治疗效果。
Brain Behav Immun. 2019 Feb;76:139-150. doi: 10.1016/j.bbi.2018.11.013. Epub 2018 Nov 16.
2
Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury.年龄会加剧小胶质细胞激活、氧化应激、炎症和 NOX2 基因表达，并延迟中年脊髓损伤啮齿动物模型的功能恢复。
J Neuroinflammation. 2017 Aug 18;14(1):161. doi: 10.1186/s12974-017-0933-3.
3
bioRxiv. 2024 Mar 14:2024.03.12.584672. doi: 10.1101/2024.03.12.584672.
4
Effects of NADPH Oxidase Isoform-2 (NOX2) Inhibition on Behavioral Responses and Neuroinflammation in a Mouse Model of Neuropathic Pain.NADPH氧化酶亚型2（NOX2）抑制对神经性疼痛小鼠模型行为反应和神经炎症的影响
Biomedicines. 2023 Jan 31;11(2):416. doi: 10.3390/biomedicines11020416.
5
Advanced Age and Neurotrauma Diminish Glutathione and Impair Antioxidant Defense after Spinal Cord Injury.高龄和神经创伤会降低脊髓损伤后的谷胱甘肽水平并损害抗氧化防御。
J Neurotrauma. 2022 Aug;39(15-16):1075-1089. doi: 10.1089/neu.2022.0010. Epub 2022 Jul 13.
6
Acute inflammatory profiles differ with sex and age after spinal cord injury.脊髓损伤后，急性炎症特征因性别和年龄而异。
J Neuroinflammation. 2021 May 13;18(1):113. doi: 10.1186/s12974-021-02161-8.
7
Mitochondria exert age-divergent effects on recovery from spinal cord injury.线粒体对脊髓损伤后的恢复有年龄差异的影响。
Exp Neurol. 2021 Mar;337:113597. doi: 10.1016/j.expneurol.2021.113597. Epub 2021 Jan 7.
8
The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System.神经元外在因素及衰老对中枢神经系统损伤进展和轴突修复的影响
Front Cell Dev Biol. 2020 Mar 25;8:190. doi: 10.3389/fcell.2020.00190. eCollection 2020.
9
Disconnected Body Representation: Neuroplasticity Following Spinal Cord Injury.脱节的身体表征：脊髓损伤后的神经可塑性
J Clin Med. 2019 Dec 4;8(12):2144. doi: 10.3390/jcm8122144.
Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice.
巨噬细胞在小鼠年龄相关氧化应激和脂褐素积累中的作用。
Redox Biol. 2017 Aug;12:423-437. doi: 10.1016/j.redox.2017.03.005. Epub 2017 Mar 9.
4
The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms.脊髓损伤后轴突修复中的年龄因素：聚焦神经元内在机制。
Neurosci Lett. 2017 Jun 23;652:41-49. doi: 10.1016/j.neulet.2016.11.003. Epub 2016 Nov 3.
5
Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury.年龄增加巨噬细胞中活性氧的产生，并增强脊髓损伤后的氧化损伤。
Neurobiol Aging. 2016 Nov;47:157-167. doi: 10.1016/j.neurobiolaging.2016.07.029. Epub 2016 Aug 6.
6
NADPH Oxidases Are Essential for Macrophage Differentiation.NADPH氧化酶对巨噬细胞分化至关重要。
J Biol Chem. 2016 Sep 16;291(38):20030-41. doi: 10.1074/jbc.M116.731216. Epub 2016 Aug 3.
7
Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System.成年哺乳动物中枢神经系统中轴突再生随年龄下降的证据。
Cell Rep. 2016 Apr 12;15(2):238-46. doi: 10.1016/j.celrep.2016.03.028. Epub 2016 Mar 31.
8
Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Propensity Score-Matched Cohort Study from a Canadian Multi-Center Spinal Cord Injury Registry.
J Neurotrauma. 2016 May 15;33(10):972-4. doi: 10.1089/neu.2016.4473.
9
Age- and location-related changes in microglial function.小胶质细胞功能随年龄和位置的变化。
Neurobiol Aging. 2015 Jun;36(6):2153-63. doi: 10.1016/j.neurobiolaging.2015.02.016. Epub 2015 Feb 23.
10
Apocynin: molecular aptitudes.鱼藤酮：分子特性。
Mediators Inflamm. 2008;2008:106507. doi: 10.1155/2008/106507. Epub 2008 Dec 2.