Song Lina, Tian Xianhai, Rudolph Matthias, Rominger Frank, Hashmi A Stephen K
Institute of Organic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Chem Commun (Camb). 2019 Aug 7;55(61):9007-9010. doi: 10.1039/c9cc04027g. Epub 2019 Jul 10.
We herein report the gold(iii)-catalyzed selective annulation of anthranils with N-allylynamides under mild conditions. By trapping the in situ-generated α-imino gold carbenes, 3-azabicyclo[3.1.0]hexan-2-imines were obtained in high synthetic efficiency. The reaction, which can be conducted in the gram scale, tolerates electron-rich and electron-deficient anthranils as well as a diverse set of functionalized ynamides (aryl- and alkyl-substituted terminal).
我们在此报告了在温和条件下金（III）催化邻氨基苯甲腈与N-烯丙基酰胺的选择性环化反应。通过捕获原位生成的α-亚氨基金卡宾，以高合成效率得到了3-氮杂双环[3.1.0]己烷-2-亚胺。该反应可以进行克级规模的操作，对富电子和缺电子的邻氨基苯甲腈以及多种官能化的炔酰胺（芳基和烷基取代的端基）均具有耐受性。
