急性乙醇处理可降低去势大鼠垂体门脉血浆促黄体生成激素释放激素（LH-RH）水平及全身血浆促黄体生成素（LH）水平。
Acute ethanol treatment lowers hypophyseal portal plasma luteinizing hormone-releasing hormone (LH-RH) and systemic plasma LH levels in orchidectomized rats.
作者信息
Ching M, Valenca M, Negro-Vilar A
机构信息
Reproductive Neuroendocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Brain Res. 1988 Mar 8;443(1-2):325-8. doi: 10.1016/0006-8993(88)91627-7.
Acute ethanol (EtOH) treatment resulted in a significant decline in hypophyseal portal plasma levels of luteinizing hormone-releasing hormone (LH-RH) in orchidectomized rats. This was accompanied by a similar decrement in circulating luteinizing hormone (LH) without, however, modifying plasma follicle-stimulating hormone (FSH) levels at time when peak blood alcohol concentrations occurred. Thus, acute alcohol intoxication lowers circulating LH levels primarily by impairing hypothalamic neuronal secretion of LH-RH into the portal blood.
急性乙醇（EtOH）处理导致去势大鼠垂体门脉血浆中促黄体生成素释放激素（LH-RH）水平显著下降。同时，循环中的促黄体生成素（LH）也出现类似下降，但在血中乙醇浓度达到峰值时，血浆促卵泡生成素（FSH）水平未发生改变。因此，急性酒精中毒主要通过损害下丘脑神经元向门脉血中分泌LH-RH来降低循环中的LH水平。
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