Complutense University of Madrid.
Psicothema. 2019 Aug;31(3):239-245. doi: 10.7334/psicothema2019.27.
Experimental substance use among young people is related to individual factors including personality traits such as impulsivity and sensation seeking, and genetic variations such as single nucleotide polymorphisms (SNPs) in the fatty acid amide hydrolase (FAAH) gene. The objective of this study is to analyze the relationship between these three sets of variables.
Volunteer undergraduate students (N = 861, 76% female, M = 20.7 years) completed an ad hoc questionnaire on variables related to their consumption of alcohol, tobacco, cannabis, synthetic drugs and cocaine. In addition, 591 of them completed the Barratt Impulsiveness Scale-11 (BIS-11) and the Sensation Seeking Scale-V (SSS-V). All participants were genotyped in FAAH C385A SNP and its proxy variant rs12075550.
Consistent with previous data, both impulsivity and sensation seeking were associated with most of the variables related to experimental substance use. In addition, we found the first evidence of an association between the rs12075550 SNP and some of these consumption phenotypes. However, no significant association was found between either of the two SNPs and impulsivity or sensation seeking.
The results highlight the importance of considering both personality and genetic differences, together with contextual factors, in the analysis of substance use.
年轻人的实验性物质使用与个体因素有关，包括冲动和寻求感觉等人格特质，以及脂肪酸酰胺水解酶（FAAH）基因中单核苷酸多态性（SNP）等遗传变异。本研究的目的是分析这三组变量之间的关系。
志愿大学生（N=861，女性占 76%，M=20.7 岁）完成了一份关于与他们的酒精、烟草、大麻、合成毒品和可卡因消费相关的变量的专门问卷。此外，其中 591 人完成了巴瑞特冲动量表-11（BIS-11）和感觉寻求量表-V（SSS-V）。所有参与者均进行了 FAAH C385A SNP 及其替代变体 rs12075550 的基因分型。
与先前的数据一致，冲动和寻求感觉都与大多数与实验性物质使用相关的变量有关。此外，我们发现了 rs12075550 SNP 与这些消费表型中的一些关联的第一个证据。然而，两个 SNP 中的任何一个与冲动或寻求感觉都没有发现显著的关联。
研究结果强调了在分析物质使用时，需要考虑人格和遗传差异，以及情境因素的重要性。
