血液半乳糖凝集素-3水平可预测结直肠癌手术后的术后并发症。
Blood Galectin-3 Levels Predict Postoperative Complications after Colorectal Cancer Surgery.
作者信息
Matsuda Akihisa, Yamada Marina, Matsumoto Satoshi, Sakurazawa Nobuyuki, Kawano Youichi, Sekiguchi Kumiko, Yamada Takeshi, Matsutani Takeshi, Miyashita Masao, Yoshida Hiroshi
机构信息
Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital.
Department of Surgery, Nippon Medical School.
出版信息
J Nippon Med Sch. 2019;86(3):142-148. doi: 10.1272/jnms.JNMS.2019_86-302.
BACKGROUND
Recent studies suggested that galectin-3 may act as a pro-inflammatory damage-associated molecular pattern. The aim of this study is to investigate the association between blood galectin-3 and postoperative complications (POC) after colorectal cancer (CRC) surgery.
METHODS
Blood samples were taken from 35 patients with CRC before surgery, immediately after surgery, and on postoperative days (POD) 1, 3, 5, and 7. Blood galectin-3 and interleukin-6 levels were measured by commercially available ELISA. Patients were divided into those with (POC group) and without POC (no-POC group).
RESULTS
Significantly higher galectin-3 levels were observed pre- and postoperatively in the POC group (n=10) compared with those of the no-POC group (n=25). Galectin-3 levels on POD1 showed the best predictive potential for POC (cut-off: 3.18 pg/mL, area under the curve: 0.868).
CONCLUSIONS
These results indicate that increased perioperative blood galectin-3 levels may be associated with POC after CRC surgery.
背景
近期研究表明，半乳糖凝集素-3可能作为一种促炎损伤相关分子模式发挥作用。本研究旨在探讨结直肠癌（CRC）手术后血液中半乳糖凝集素-3与术后并发症（POC）之间的关联。
方法
采集35例CRC患者术前、术后即刻以及术后第1、3、5和7天的血样。采用市售酶联免疫吸附测定（ELISA）法检测血液中半乳糖凝集素-3和白细胞介素-6水平。将患者分为发生POC的患者（POC组）和未发生POC的患者（无POC组）。
结果
与无POC组（n = 25）相比，POC组（n = 10）术前和术后半乳糖凝集素-3水平显著更高。术后第1天的半乳糖凝集素-3水平对POC具有最佳预测潜力（临界值：3.18 pg/mL，曲线下面积：0.868）。
结论
这些结果表明，围手术期血液半乳糖凝集素-3水平升高可能与CRC手术后的POC相关。
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