a School of Pharmacy, Nantong University , Nantong , China.
b Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University , Yangzhou , China.
Drug Deliv. 2019 Dec;26(1):717-723. doi: 10.1080/10717544.2019.1639846.
Proteins such as albumin, gelatin, casein, transferrin, and collagen are widely used as drug delivery systems. However, only albumin-based paclitaxel (PTX) formulation Abraxane (PTX-albumin NPs prepared by nab-technology) has been successfully developed for treating metastatic breast cancer clinically due to abundant materials, simple industrial scale-up process, and well tumor-targeting ability. Hemoglobin (Hb) is another protein used for drug delivery with similar advantages. In this study, we successfully synthesized PEG-Hb nanoparticles loading with PTX based on previously well-established acid-denatured method. PEG-Hb-PTX NPs showed enhanced cellular uptake and great cellular inhibition ability . Moreover, our animal study showed that PEGylated NPs greatly accumulated in tumor tissues and exhibited excellent anticancer activity We found that PEG-Hb-PTX NPs possess a better antitumor effect than the commercially available Taxol formulation. We believe that PEG-Hb has great potential as an efficient drug delivery system for further clinic study.
蛋白质，如白蛋白、明胶、酪蛋白、转铁蛋白和胶原蛋白，被广泛用作药物传递系统。然而，由于材料丰富、工业放大过程简单以及良好的肿瘤靶向能力，只有基于白蛋白的紫杉醇（PTX）制剂 Abraxane（通过 nab 技术制备的 PTX-白蛋白 NPs）已成功开发用于治疗转移性乳腺癌。血红蛋白（Hb）是另一种用于药物输送的蛋白质，具有类似的优势。在本研究中，我们成功地合成了基于先前建立的酸变性方法负载紫杉醇的 PEG-Hb 纳米颗粒。PEG-Hb-PTX NPs 显示出增强的细胞摄取和强大的细胞抑制能力。此外，我们的动物研究表明，PEG 化纳米颗粒在肿瘤组织中大量积累，并表现出优异的抗癌活性。我们发现，PEG-Hb-PTX NPs 比市售的 Taxol 制剂具有更好的抗肿瘤作用。我们相信，PEG-Hb 作为一种高效的药物传递系统具有很大的潜力，值得进一步进行临床研究。
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