TIMP-2 通过调节 MMP-9 抑制结直肠癌转移并预测预后。
TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9.
机构信息
a Institute of Traslational Medicine , Medical College, Yangzhou University , Yangzhou , PR China.
b The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine , Yangzhou , PR China.
出版信息
Cell Adh Migr. 2019 Dec;13(1):273-284. doi: 10.1080/19336918.2019.1639303.
Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a CRC tissue microarray by immunohistochemistry. We found that lower TIMP-2 or/and higher MMP-9 expression in cancer tissues was correlated with poorer overall survival (OS). TIMP-2 or MMP-9 expression was independent prognostic factors for CRC. Furthermore, TIMP-2 and MMP-9 expression had a synergistic role as efficient prognostic indicators for CRC patients. In vitro and in vivo, TIMP-2 could inhibit HCT 116 cells invasion and migration by regulating MMP-9. In sum, a combined expression of TIMP-2 and MMP-9 as efficient prognostic indicators was found for the first time.
结直肠癌具有常见的发病率和死亡率。因此，迫切需要检测可靠的生物标志物来预测 CRC 的预后。在这里，我们通过免疫组织化学法测定了 TIMP-2 和 MMP-9 在 CRC 组织微阵列中的表达。我们发现，癌组织中 TIMP-2 表达降低或/和 MMP-9 表达升高与总生存期（OS）较差相关。TIMP-2 或 MMP-9 表达是 CRC 的独立预后因素。此外，TIMP-2 和 MMP-9 的表达作为 CRC 患者有效的预后指标具有协同作用。在体外和体内，TIMP-2 通过调节 MMP-9 抑制 HCT 116 细胞的侵袭和迁移。总之，首次发现 TIMP-2 和 MMP-9 的联合表达是有效的预后指标。
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