Zhang Lin, Wang Dan, Han Xiao, Tang Furong, Gao Dianshuai
School of Nursing of Xuzhou Medical University, Xuzhou, Jiangsu province, 221004, China.
Department of Anatomy and Neurobiology of Xuzhou Medical University, Xuzhou, Jiangsu province, 221004, China.
Heliyon. 2019 Jun 19;5(6):e01951. doi: 10.1016/j.heliyon.2019.e01951. eCollection 2019 Jun.
Gliomas are the most common primary malignant tumors in the central nervous system. High expression of glial cell line-derived neurotrophic factor (GDNF) is an important prerequisite for the initiation and development of gliomas. However, the underlying transcription mechanism is poorly understood. Epigenetic alterations are common and important hallmarks of various types of tumors, and lead to abnormal expression of genes. Several recent studies have suggested that epigenetic modifications contribute to increased transcription. Specifically, aberrant DNA methylation and histone acetylation in the promoter regions of are related to high transcription in glioma cells, where transcription factors have extremely important roles. Therefore, elucidating the importance and features of this underlying molecular mechanism will enhance our understanding and provide clues for the accurate diagnosis and efficacious treatment of gliomas. This review summarizes the latest thinking on the potential epigenetic mechanisms of high expression of in glioma cells focusing primarily on DNA methylation and histone acetylation.
神经胶质瘤是中枢神经系统中最常见的原发性恶性肿瘤。胶质细胞源性神经营养因子（GDNF）的高表达是神经胶质瘤发生和发展的重要前提。然而，其潜在的转录机制尚不清楚。表观遗传改变是各类肿瘤常见且重要的特征，并导致基因异常表达。最近的几项研究表明，表观遗传修饰会促进转录增加。具体而言，胶质瘤细胞中启动子区域异常的DNA甲基化和组蛋白乙酰化与高转录相关，其中转录因子起着极其重要的作用。因此，阐明这一潜在分子机制的重要性和特征将增进我们的理解，并为神经胶质瘤的准确诊断和有效治疗提供线索。本综述总结了关于胶质瘤细胞中GDNF高表达潜在表观遗传机制的最新观点，主要聚焦于DNA甲基化和组蛋白乙酰化。
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