Public Experimental Research Center, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Mol Neurobiol. 2021 Jun;58(6):2634-2642. doi: 10.1007/s12035-020-02240-6. Epub 2021 Jan 22.
Failed neuroprotection leads to the initiation of several diseases. SOX1 plays many roles in embryogenesis, oncogenesis, and male sex determination, and can promote glioma stem cell proliferation, invasion, and migration due to its high expression in glioblastoma cells. The functional versatility of the SOX1 gene in malignancy, epilepsy, and Parkinson's disease, as well as its adverse effects on dopaminergic neurons, makes it an interesting research focus. Hence, we collate the most important discoveries relating to the neuroprotective effects of SOX1 in brain cancer and propose hypothesis worthy of SOX1's role in the survival of senescent neuronal cells, its roles in fibroblast cell proliferation, and cell fat for neuroprotection, and the discharge of electrical impulses for homeostasis. Increase in electrical impulses transmitted by senescent cells affects the synthesis of neurotransmitters, which will modify the brain cell metabolism and microenvironment.
神经保护失败会导致多种疾病的发生。SOX1 在胚胎发生、肿瘤发生和男性性别决定中发挥多种作用，并且由于其在神经胶质瘤细胞中的高表达，可促进神经胶质瘤干细胞的增殖、侵袭和迁移。SOX1 基因在恶性肿瘤、癫痫和帕金森病中的功能多样性及其对多巴胺能神经元的不利影响，使其成为一个有趣的研究焦点。因此，我们整理了与 SOX1 在脑癌中的神经保护作用相关的最重要发现，并提出假说，值得关注 SOX1 在衰老神经元细胞存活中的作用、其在成纤维细胞增殖和细胞脂肪中的作用，以及电脉冲在维持平衡中的作用。衰老细胞传递的电脉冲增加会影响神经递质的合成，从而改变脑细胞代谢和微环境。
