脂质对大鼠大脑皮层中膜相关环磷酸腺苷磷酸二酯酶的可能调节作用。
Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids.
作者信息
Baba A, Tsukamoto T, Matsuda T, Iwata H
出版信息
Experientia. 1978 Sep 15;34(9):1139-40. doi: 10.1007/BF01922916.
PMID:31295
Abstract
Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++.
摘要
大鼠大脑皮层膜组分中的环磷酸腺苷磷酸二酯酶（PDE）可被 Triton X - 100、在碱性 pH 条件下处理以及用磷脂酶 C 激活。这些结果表明膜 PDE 以潜伏形式存在，并受膜内微环境变化的影响。此外，与可溶性酶不同，该 PDE 不受蛋白质激活剂和 Ca++ 的影响。
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