HIV-1 药物逃逸对全球治疗格局的影响。

The Impact of HIV-1 Drug Escape on the Global Treatment Landscape.

机构信息

Division of Infection and Immunity, University College London, London, UK.

Department of Medicine, University of Cambridge, Cambridge, UK.

出版信息

Cell Host Microbe. 2019 Jul 10;26(1):48-60. doi: 10.1016/j.chom.2019.06.010.

DOI:10.1016/j.chom.2019.06.010

PMID:31295424

Abstract

The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in clinical use, this Review critically summarizes what is known about the mechanisms the virus utilizes to escape drug control. Armed with this knowledge, strategies to limit the expansion of HIVDR are proposed.

摘要

HIV 耐药性（HIVDR）的流行率不断上升，可能会威胁到在抗击艾滋病流行方面取得的成果，并影响到联合国艾滋病规划署（UNAIDS）提出的 90-90-90 目标，该目标旨在到 2020 年使接受抗逆转录病毒疗法（ART）的所有人中 90%达到病毒学抑制。HIVDR 对 HIV 的持续存在、当前和未来 ART 药物方案的选择以及疫苗和治愈策略的开发具有影响。本文重点关注临床应用的药物类别，批判性地总结了病毒用于逃避药物控制的机制。有了这些知识，就可以提出限制 HIVDR 扩展的策略。