Infectious Diseases Department, Liège University Hospital, 4000 Liège, Belgium.
Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Viruses. 2020 Apr 27;12(5):489. doi: 10.3390/v12050489.
In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong. Persistence of viral reservoirs forms the major obstacle to an HIV cure. HIV latent reservoirs persist primarily by cell longevity and proliferation, but replenishment by residual virus replication despite ART has been proposed as another potential mechanism of HIV persistence. It is a matter of debate whether different ART regimens are equally potent in suppressing HIV replication. Here, we summarized the current knowledge on the role of ART regimens in HIV persistence, focusing on differences in residual plasma viremia and other virological markers of the HIV reservoir between infected individuals treated with combination ART composed of different antiretroviral drug classes.
在依从性好的个体中，抗逆转录病毒疗法（ART）可抑制 HIV 复制，恢复免疫功能，并预防 AIDS 的发生。然而，ART 并不能治愈 HIV，且必须终身服用。病毒储存库的持续存在是 HIV 治愈的主要障碍。HIV 潜伏储存库主要通过细胞寿命和增殖而持续存在，但尽管进行了 ART 治疗，仍有残余病毒复制被提出是 HIV 持续存在的另一个潜在机制。不同的 ART 方案在抑制 HIV 复制方面的效力是否相同，这是一个有争议的问题。在这里，我们总结了目前关于 ART 方案在 HIV 持续存在中的作用的知识，重点关注接受不同抗逆转录病毒药物类别组成的联合 ART 治疗的感染者体内的血浆残余病毒血症和 HIV 储存库的其他病毒学标志物的差异。
