Koch W M, Dugan E, Diaz L A, Richtsmeier W J
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Laryngoscope. 1988 May;98(5):511-5. doi: 10.1288/00005537-198805000-00007.
The antigen recognition system which plays the major role in immunologic attraction mechanisms, including graft rejection, is the class II major histocompatibility complex containing the HLA-DR locus. Few types of cells constitutively express this antigen, as it is a potent immunological activating signal usually confined to antigen processing cells, activated lymphocytes, and endothelium. Using indirect immunofluorescence, we have observed induction of the HLA-DR glycoprotein in selected head and neck squamous cell carcinoma tissue cultures treated with recombinant interferon gamma. This occurs in concert with growth arrest and morphological changes after rHuIFN-gamma treatment. This report describes the induction of a surface antigen that may have profound prognostic significance. Understanding the kinetics of HLA-DR induction will aid in the design and assessment of adoptive immunotherapy with rHuIFN-gamma.
在免疫吸引机制（包括移植排斥）中起主要作用的抗原识别系统是包含HLA - DR基因座的II类主要组织相容性复合体。很少有细胞类型组成性地表达这种抗原，因为它是一种强大的免疫激活信号，通常局限于抗原加工细胞、活化的淋巴细胞和内皮细胞。通过间接免疫荧光法，我们观察到在用重组干扰素γ处理的选定头颈部鳞状细胞癌组织培养物中HLA - DR糖蛋白的诱导。这与重组人干扰素γ处理后的生长停滞和形态变化同时发生。本报告描述了一种可能具有深远预后意义的表面抗原的诱导。了解HLA - DR诱导的动力学将有助于设计和评估重组人干扰素γ的过继免疫疗法。
