Baxter Healthcare Corporation, Renal Division, Deerfield, IL, USA
Renal Electrolyte Division at The University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Perit Dial Int. 2019 Jul-Aug;39(4):299-305. doi: 10.3747/pdi.2018.00209.
Peritonitis is the leading cause of transfer from peritoneal dialysis (PD) to hemodialysis (HD). It is also the leading cause of hospitalization of PD patients. The usual treatment of peritonitis for automated PD (APD) patients consists of antibiotics given once daily in the long dwell. However, the once-daily antibiotic dosing recommendations are based primarily on studies with continuous ambulatory PD (CAPD) regimens. Published studies on antibiotic dosing in APD are very limited. We will review the scant literature on this topic. It is possible that extrapolating once-daily dosing from CAPD to APD may lead to underdosing. There is a need for further pharmacokinetic studies of antibiotic dosing in APD.
腹膜炎是腹膜透析（PD）转为血液透析（HD）的主要原因。它也是 PD 患者住院的主要原因。自动化 PD（APD）患者腹膜炎的常规治疗包括在长留置时间内每天一次给予抗生素。然而，每日一次的抗生素剂量建议主要基于连续流动 PD（CAPD）方案的研究。关于 APD 中抗生素剂量的已发表研究非常有限。我们将回顾这一主题的少量文献。从 CAPD 推断出 APD 的每日一次剂量可能会导致剂量不足。因此，需要进一步研究 APD 中抗生素剂量的药代动力学。
