一例费城染色体阳性急性淋巴细胞白血病合并曲霉菌脑脓肿和侵袭性肺曲霉菌病患者，先接受伏立康唑治疗，随后进行脐血移植，治疗成功。
A Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Aspergillus Brain Abscess and Invasive Pulmonary Aspergillosis Successfully Treated with Voriconazole Followed by Cord Blood Transplantation.
作者信息
Sekiguchi Yasunobu, Wakabayashi Mutsumi, Takizawa Haruko, Iizuka Hiroko, Sakajiri Sakura, Sugimoto Keiji, Inano Tadaaki, Fukuda Yasutaka, Hamano Yasuharu, Tomita Shigeki, Izumi Hiroshi, Okubo Mitsuo, Nakamura Noriko, Sawada Tomohiro, Noguchi Masaaki
机构信息
Dept. of Hematology, Juntendo University Urayasu Hospital.
出版信息
Gan To Kagaku Ryoho. 2019 Jul;46(7):1203-1209.
A 59-year-old female was diagnosed as pulmonary aspergillosis(IPA)while remission induction therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia. Liposomal amphotericin B improved the fungal serodiagnostic markers, however,the IPA worsened. She also developed an Aspergillus brain abscess,which, while being undetectable on CT,was detected as multiple nodular lesions by MRI. A definitive diagnosis was made by polymerase chain reaction(PCR)of brain biopsy specimens. Voriconazole(VRCZ)was effective,and cord blood transplantation was performed. She has received VRCZ for a long time. There are no relapse of either the IPA or the Aspergillus brain abscess.
一名59岁女性在接受费城染色体阳性急性淋巴细胞白血病缓解诱导治疗时被诊断为肺曲霉病（IPA）。脂质体两性霉素B改善了真菌血清学诊断指标，然而，IPA病情却恶化了。她还出现了曲霉性脑脓肿，CT检查未发现，但MRI检查发现为多个结节性病变。通过脑活检标本的聚合酶链反应（PCR）做出了明确诊断。伏立康唑（VRCZ）治疗有效，并进行了脐血移植。她长期接受VRCZ治疗。IPA和曲霉性脑脓肿均未复发。
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