Georgiev I, Belopitova L, Alexiev A
Medizinische Akademie Sofia, Institut für Neurologie, Psychiatrie und Neurochirurgie.
Psychiatr Neurol Med Psychol (Leipz). 1988 Jan;40(1):16-25.
Clinical--electroencephalographic (EEG) investigation was performed in 12 families. In the study were included 12 epileptics with partial seizures in whom the katamnestic follow up from 2 to 6 years provided clinical, EEG and genetic data for the so called primary partial epilepsy 24 parents and 14 siblings. In four of the Children with epilepsy the seizures were of the "Rolandic" type; in 5--"psychomotor"; and in 3--hemiconvulsive. No data for structural brain lesion investigation were found. Rapid and long lasting therapeutic effect was achieved in all of the cases. The EEG showed focal paroxysmal activity in all of the diseased and in 11 of the siblings, in 5 of them were found epileptic seizures of the same type as in the probands. The possibilities of a genetic predisposition to development of an epileptogenic focus and its clinical Expression in members of the families in discussed.
对12个家庭进行了临床-脑电图（EEG）研究。该研究纳入了12名部分性发作的癫痫患者，对其进行了2至6年的随访，获取了所谓原发性部分性癫痫患者的临床、脑电图和基因数据，还包括24名父母和14名兄弟姐妹的数据。4名癫痫患儿的发作类型为“罗兰多”型；5名是“精神运动性”发作；3名是半身惊厥性发作。未发现脑结构性病变的检查数据。所有病例均取得了快速且持久的治疗效果。脑电图显示，所有患病者及11名兄弟姐妹均有局灶性阵发性活动，其中5人的癫痫发作类型与先证者相同。本文讨论了家族成员中癫痫病灶发生遗传易感性及其临床表型的可能性。
