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损伤控制性剖腹术的质量改进:建立单一韩国区域性创伤中心的影响。

Quality Improvement of Damage Control Laparotomy: Impact of the Establishment of a Single Korean Regional Trauma Center.

机构信息

Division of Trauma Surgery, Department of Surgery, Chonnam National University Hospital and Medical School, 42, Jebong-ro, Dong-gu, Gwangju, Korea.

Department of Trauma Surgery, Wonkwang University Hospital, Iksan, Korea.

出版信息

World J Surg. 2019 Nov;43(11):2814-2821. doi: 10.1007/s00268-019-05083-y.

Abstract

BACKGROUND

Damage control laparotomy (DCL) is a lifesaving technique to minimize the lethal triad of coagulopathy, hypothermia, and acidosis. The government has nominated and supported our center as one of the regional trauma centers of South Korea since 2014. This study aimed to investigate the improving outcomes of patients undergoing DCL before and after the establishment of the trauma center.

METHOD

The period from January 2011 to December 2017 was divided into pre-trauma center (pre-TC) (2011-2013) and trauma center (TC) (2014-2017) periods. Multivariable logistic regression was performed to identify the risk factors and risk-adjusted cumulative sum (RA-CUSUM), and graphs were used to monitor the change in mortality.

RESULT

Of the 485 patients who underwent trauma laparotomy, DCL was performed for 119 patients (24.5%). The operation time (99 vs. 80 min, p = 0.022), time from admission to operation (125 vs. 112 min, p = 0.010), time from admission to first treatment (119 vs. 99 min, p = 0.004), and time from admission to first transfusion (70 vs. 52 min, p = 0.009) were significantly shortened in the TC period. The ratio of plasma to packed red blood cells in massive transfusions (≥PRBCs 10 units within the first 24 h) was significantly increased in the TC period (0.56 vs. 0.72, p = 0.004). RA-CUSUM curves revealed that the risk-adjusted 30-day mortality improved and then plateaued in the TC period.

CONCLUSION

After the implementation of a trauma center, more prompt intervention and damage control resuscitation could be achieved. Moreover, risk-adjusted mortality of DCL was improved.

摘要

背景

损伤控制性剖腹术(DCL)是一种挽救生命的技术,可以最大限度地减少凝血功能障碍、低体温和酸中毒的致死三联征。自 2014 年以来,政府已提名并支持我们中心作为韩国区域创伤中心之一。本研究旨在调查创伤中心建立前后接受 DCL 的患者结局的改善情况。

方法

将 2011 年 1 月至 2017 年 12 月分为创伤中心前(TC)时期(2011-2013 年)和创伤中心(TC)时期(2014-2017 年)。采用多变量逻辑回归分析确定风险因素和风险调整累积和(RA-CUSUM),并用图形监测死亡率的变化。

结果

在接受创伤剖腹术的 485 例患者中,有 119 例(24.5%)接受了 DCL。TC 时期的手术时间(99 分钟比 80 分钟,p=0.022)、从入院到手术的时间(125 分钟比 112 分钟,p=0.010)、从入院到首次治疗的时间(119 分钟比 99 分钟,p=0.004)和从入院到首次输血的时间(70 分钟比 52 分钟,p=0.009)均明显缩短。在 TC 时期,大量输血(24 小时内输注 PRBCs 10 个单位以上)中血浆与浓缩红细胞的比例显著增加(0.56 比 0.72,p=0.004)。RA-CUSUM 曲线显示,TC 时期风险调整后的 30 天死亡率提高,然后趋于平稳。

结论

实施创伤中心后,可实现更及时的干预和损伤控制性复苏,而且 DCL 的风险调整死亡率得到改善。

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