Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain.
Adv Exp Med Biol. 2019;1154:71-103. doi: 10.1007/978-3-030-18616-6_4.
Fascioliasis is a major parasitic disease caused by the digenetic trematodes Fasciola hepatica and Fasciola gigantica. The disease is a well-known veterinary problem of worldwide distribution. Fascioliasis is the vector-borne parasitic disease presenting the widest latitudinal, longitudinal, and altitudinal distribution known at present. In the last two decades, many surveys have shown it to be an important public health problem as well, including estimations of 2.4 million, up to 17 million people, or even higher depending on the hitherto unknown situations mainly in several regions of Asia and Africa. In recent years, the increasing number of human case reports in many countries of the five continents and the results of studies on pathogenicity and immunity, mainly regarding the chronic period of the disease, were the reasons why it was decided to no longer consider fascioliasis merely a secondary zoonotic disease but an important human parasitic disease. In this chapter, we review the most relevant features in relation to fascioliasis, including from the most traditional to the most innovative aspects.
片形吸虫病是一种由双腔吸虫属的肝片形吸虫和巨片形吸虫引起的主要寄生虫病。该病是一种分布广泛的著名兽医问题。片形吸虫病是目前已知分布最广的带虫媒介寄生虫病，在纬度、经度和海拔上均有分布。在过去的二十年中，许多调查表明它也是一个重要的公共卫生问题，包括估计有 240 万人，多达 1700 万人，甚至更高，这取决于在亚洲和非洲的几个地区目前尚不清楚的情况。近年来，在五大洲的许多国家中，人类病例报告的数量不断增加，以及对致病性和免疫性的研究结果，主要是关于疾病的慢性期，这是决定不再将片形吸虫病仅仅视为次要的人畜共患病，而是一种重要的人类寄生虫病的原因。在这一章中，我们回顾了与片形吸虫病相关的最相关特征，包括从最传统到最创新的方面。
