Virology Department, Centre Pasteur of Cameroon, Yaoundé, Cameroon.
Department of Animals Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
J Med Virol. 2019 Nov;91(11):1989-1994. doi: 10.1002/jmv.25545. Epub 2019 Jul 23.
Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. HEV infection is self-limiting, but fulminant hepatitis may occur with higher mortality rates. The aim of this study was to determine the seroprevalence of the HEV in three different populations in Cameroon and to assess alimentary risk factors of infection. A total of 903 individuals including 450 elderly people, 183 pregnant women, and 270 HIV-infected patients were enrolled during 2009-2015. All sera obtained were tested for the presence of anti-HEV antibodies with commercial enzyme-linked immunosorbent assay kits. The association between initial anti-HEV status and potential risk factors was assessed. Out of the 903 samples, 22.0% (199/903) were positives for anti-HEV immunoglobulin M (IgM), 5.8% (52/903) for anti-HEV IgG, and 3.5% (32/903) for both. The seropositivity for IgM was 7.0%, 13.1%, and 34.7%; meanwhile, the seropositivity for immunoglobulin G was 8.5%, 3.3%, and 5.1%, in HIV-infected patients, pregnant women, and the elderly population, respectively. Both antibodies were detected simultaneously in 2.2%, 1.6%, and 5.1% in HIV-infected patients, pregnant women, and the elderly population, respectively. No risk factors were significantly associated with HEV infection in these populations. This study showed a high prevalence of anti-HEV antibodies in three different populations in Cameroon.
戊型肝炎病毒（HEV）是全球范围内急性肝炎的主要病因。HEV 感染具有自限性，但暴发性肝炎可能导致更高的死亡率。本研究旨在确定喀麦隆三个不同人群中的 HEV 血清流行率，并评估感染的饮食危险因素。2009-2015 年间共纳入 903 名个体，包括 450 名老年人、183 名孕妇和 270 名 HIV 感染者。所有获得的血清均采用商业酶联免疫吸附试验试剂盒检测抗-HEV 抗体的存在。评估初始抗-HEV 状态与潜在危险因素之间的关联。在 903 个样本中，22.0%（199/903）为抗-HEV 免疫球蛋白 M（IgM）阳性，5.8%（52/903）为抗-HEV IgG 阳性，3.5%（32/903）为两者均阳性。IgM 的血清阳性率为 7.0%、13.1%和 34.7%；同时，IgG 的血清阳性率分别为 HIV 感染者、孕妇和老年人中的 8.5%、3.3%和 5.1%。两种抗体在 HIV 感染者、孕妇和老年人中的同时检出率分别为 2.2%、1.6%和 5.1%。在这些人群中，没有发现危险因素与 HEV 感染显著相关。本研究表明，喀麦隆三个不同人群中的抗-HEV 抗体流行率较高。
