Department of Medicine, Division of Nephrology, Koç University School of Medicine, Istanbul, Turkey.
Department of Medicine, School of Medicine, Koç University, Istanbul, Turkey.
Diabetes Obes Metab. 2019 Nov;21(11):2368-2383. doi: 10.1111/dom.13831. Epub 2019 Jul 29.
Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes. Although it is recognized that glomerular hyperfiltration, that is, increased filtration per nephron unit (usually studied at low glomerular filtration levels and often referred to as single nephron hyperfiltration), is a risk factor for the progression of chronic kidney disease, the implications of having renal hyperfiltration for cardiovascular disease and mortality risk are incompletely understood. Recent evidence from diverse populations, including healthy individuals and patients with diabetes or established cardiovascular disease, suggests that renal hyperfiltration is associated with a higher risk of cardiovascular disease and all-cause mortality. In this review, we critically summarize the existing studies, discuss possible mechanisms, and describe the remaining gaps in our knowledge regarding the association of renal hyperfiltration with cardiovascular disease and mortality risk.
肾高滤过，定义为肾小球滤过率高于正常水平，与各种情况下的肾脏疾病早期阶段相关，如肥胖和糖尿病。虽然已经认识到肾小球高滤过，即每个肾单位的滤过增加（通常在肾小球滤过水平较低时研究，通常称为单肾单位高滤过），是慢性肾脏病进展的危险因素，但肾高滤过对心血管疾病和死亡率风险的影响尚不完全清楚。最近来自不同人群的证据，包括健康个体以及患有糖尿病或已确诊心血管疾病的患者，表明肾高滤过与心血管疾病和全因死亡率的风险增加相关。在这篇综述中，我们批判性地总结了现有研究，讨论了可能的机制，并描述了我们在肾高滤过与心血管疾病和死亡率风险关联方面的知识空白。
