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Redefining glomerular hyperfiltration: pathophysiology, clinical implications, and novel perspectives.

作者信息

Kishi Seiji

机构信息

Department of Nephrology and Hypertension, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

出版信息

Hypertens Res. 2025 Mar;48(3):1176-1178. doi: 10.1038/s41440-024-02092-w. Epub 2025 Jan 16.

DOI:10.1038/s41440-024-02092-w
PMID:39814970
Abstract
摘要

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Redefining glomerular hyperfiltration: pathophysiology, clinical implications, and novel perspectives.重新定义肾小球高滤过:病理生理学、临床意义及新观点
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2
Definition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder.考虑到肥胖和糖耐量异常的肾脏供体候选者肾功能随年龄下降的情况下,对超滤的定义。
Hypertens Res. 2025 Mar;48(3):1115-1124. doi: 10.1038/s41440-024-02020-y. Epub 2024 Dec 12.
3
Increased risk of glomerular hyperfiltration in subjects with impaired glucose tolerance and newly diagnosed diabetes.糖耐量受损和新诊断糖尿病患者肾小球高滤过风险增加。
Nephrol Dial Transplant. 2016 Aug;31(8):1295-301. doi: 10.1093/ndt/gfv385. Epub 2015 Nov 25.
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Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study.一般非糖尿病人群中前驱糖尿病与肾小球高滤过和白蛋白尿风险:一项前瞻性队列研究。
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5
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PLoS One. 2015 Sep 14;10(9):e0137163. doi: 10.1371/journal.pone.0137163. eCollection 2015.
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Rapid GFR decline is associated with renal hyperfiltration and impaired GFR in adults with Type 1 diabetes.在1型糖尿病成人患者中,肾小球滤过率(GFR)快速下降与肾脏高滤过及GFR受损有关。
Nephrol Dial Transplant. 2015 Oct;30(10):1706-11. doi: 10.1093/ndt/gfv121. Epub 2015 Jun 6.
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Glomerular hyperfiltration.肾小球高滤过。
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Marked association between obesity and glomerular hyperfiltration: a cross-sectional study in an African population.肥胖与肾小球高滤过之间存在显著关联:一项在非洲人群中的横断面研究。
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MAFLD and glomerular hyperfiltration in subjects with normoglycemia, prediabetes and type 2 diabetes: A cross-sectional population study.血糖正常、糖尿病前期和 2 型糖尿病患者的 MAFLD 和肾小球高滤过:一项横断面人群研究。
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Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice.抑制钠依赖性葡萄糖重吸收可使清醒的腺苷A₁受体缺陷小鼠中糖尿病诱导的肾小球高滤过恢复正常。
Acta Physiol (Oxf). 2014 Feb;210(2):440-5. doi: 10.1111/apha.12152. Epub 2013 Aug 27.

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Int J Mol Sci. 2025 Jun 7;26(12):5474. doi: 10.3390/ijms26125474.

本文引用的文献

1
Glomerular hyperfiltration as a therapeutic target for CKD.肾小球高滤过作为 CKD 的治疗靶点。
Nephrol Dial Transplant. 2024 Jul 31;39(8):1228-1238. doi: 10.1093/ndt/gfae027.
2
Dapagliflozin and Prevention of Kidney Disease Among Patients With Type 2 Diabetes: Post Hoc Analyses From the DECLARE-TIMI 58 Trial.达格列净与 2 型糖尿病患者的肾脏疾病预防:DECLARE-TIMI 58 试验的事后分析。
Diabetes Care. 2022 Oct 1;45(10):2350-2359. doi: 10.2337/dc22-0382.
3
Glomerular hyperfiltration.肾小球高滤过。
Nat Rev Nephrol. 2022 Jul;18(7):435-451. doi: 10.1038/s41581-022-00559-y. Epub 2022 Apr 1.
4
Renal physiology of glucose handling and therapeutic implications.葡萄糖处理的肾脏生理学及其治疗意义。
Nephrol Dial Transplant. 2020 Jan 1;35(Suppl 1):i3-i12. doi: 10.1093/ndt/gfz230.
5
Renal hyperfiltration defined by high estimated glomerular filtration rate: A risk factor for cardiovascular disease and mortality.肾高滤过定义为高估计肾小球滤过率:心血管疾病和死亡的危险因素。
Diabetes Obes Metab. 2019 Nov;21(11):2368-2383. doi: 10.1111/dom.13831. Epub 2019 Jul 29.
6
Obesity, kidney dysfunction and hypertension: mechanistic links.肥胖、肾功能障碍和高血压:机制联系。
Nat Rev Nephrol. 2019 Jun;15(6):367-385. doi: 10.1038/s41581-019-0145-4.
7
Association of Albuminuria With Intraglomerular Hydrostatic Pressure and Insulin Resistance in Subjects With Impaired Fasting Glucose and/or Impaired Glucose Tolerance.白蛋白尿与空腹血糖受损和/或糖耐量受损患者肾小球内静水压力和胰岛素抵抗的关系。
Diabetes Care. 2018 Nov;41(11):2414-2420. doi: 10.2337/dc18-0718. Epub 2018 Sep 13.
8
Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment.糖尿病中的肾小球高滤过:机制、临床意义及治疗
J Am Soc Nephrol. 2017 Apr;28(4):1023-1039. doi: 10.1681/ASN.2016060666. Epub 2017 Jan 31.
9
Role of insulin resistance in kidney dysfunction: insights into the mechanism and epidemiological evidence.胰岛素抵抗在肾功能障碍中的作用:机制探讨和流行病学证据。
Nephrol Dial Transplant. 2013 Jan;28(1):29-36. doi: 10.1093/ndt/gfs290. Epub 2012 Oct 9.
10
Effect of gender on the progression of nondiabetic renal disease: a meta-analysis.性别对非糖尿病性肾病进展的影响:一项荟萃分析。
J Am Soc Nephrol. 2000 Feb;11(2):319-329. doi: 10.1681/ASN.V112319.