[健康人群及呼吸道过敏患者的人类白细胞抗原（HLA）和免疫球蛋白E（IgE）系统研究]

[Study of the HLA and IgE systems in healthy persons and in patients with allergies of the respiratory tract].

作者信息

Gurgenidze G V, Gamkrelidze A G, Gotua M A

出版信息

Ter Arkh. 1988;60(1):54-6.

Abstract

The purpose of the paper is to study the association of HLA-antigens and serum levels of IgE in healthy persons and patients with allergic diseases of the respiratory tracts in Georgian population. Research showed the association of the HLA-system and genes controlling serum levels of IgE. The association of comparatively low levels of IgE with antigens HLA-A11, B35, Cw4, and of a raised level with B7 and Cw2 antigens was established in healthy subjects. Healthy persons carrying antigen B7 and residents of the endemic zone of ragweed spreading formed a group at high risk of developing hyper-IgE response and ragweed pollinosis. Production of specific IgE antibodies was clearly correlated with certain HLA-antigens whereas the association of the HLA-system with total IgE levels was less marked and was revealed at comparatively low (less than 213.55 kU/l) or at significantly raised (over 433.41 kU/l) levels of total IgE. Development of hyper-IgE response (over 1000 kU/l) was associated with HLA-A3 (RR = 2.2; delta = 0.21).

摘要

本文的目的是研究格鲁吉亚人群中健康个体以及患有呼吸道过敏性疾病的患者体内HLA抗原与IgE血清水平之间的关联。研究表明HLA系统与控制IgE血清水平的基因之间存在关联。在健康受试者中，已证实IgE水平相对较低与HLA-A11、B35、Cw4抗原相关，而IgE水平升高与B7和Cw2抗原相关。携带B7抗原的健康个体以及豚草传播疫区的居民构成了发生高IgE反应和豚草花粉症的高风险群体。特异性IgE抗体的产生与某些HLA抗原明显相关，而HLA系统与总IgE水平的关联则不太显著，且在总IgE水平相对较低（低于213.55 kU/l）或显著升高（超过433.41 kU/l）时才显现出来。高IgE反应（超过1000 kU/l）的发生与HLA-A3相关（相对危险度=2.2；δ=0.21）。