Oishi Yuka, Yamakawa Tatsushi, Nagasawa Hikaru, Suzuki Kyoko
Department of Clinical Neuroscience, Yamagata University Graduate School of Medicine , Yamagata , Japan.
Department of Speech, Language, and Hearing Sciences, Niigata University of Health and Welfare , Niigata , Japan.
Neurocase. 2019 Oct;25(5):177-186. doi: 10.1080/13554794.2019.1642359. Epub 2019 Jul 12.
Topographical disorientation (TD) in novel environments is considered to be a part of anterograde amnesia. A 56-year-old woman presented with pure TD only in novel environments following limbic encephalitis. She could not remember directions inside the hospital on weekly outpatient visits; however, her verbal and visual anterograde memories were normal. In the test of learning photographs of scenes, faces, and objects, only her scores for landscapes were worse than those in healthy controls. These findings suggested that her TD specific to landscapes and directions in novel environments was caused by category-specific memory impairment related to bilateral hippocampal and parahippocampal dysfunction.
在新环境中的地形定向障碍（TD）被认为是顺行性遗忘的一部分。一名56岁女性在患边缘性脑炎后仅在新环境中出现单纯的TD。她在每周的门诊就诊时记不住医院内的方向；然而，她的言语和视觉顺行性记忆正常。在学习场景、面孔和物体照片的测试中，只有她的风景照片得分比健康对照组差。这些发现表明，她在新环境中特定于风景和方向的TD是由与双侧海马和海马旁回功能障碍相关的类别特异性记忆损害引起的。
