New-born ICU, Dongying People's Hospital, Dongying, P.R. China.
Eur Rev Med Pharmacol Sci. 2019 Jul;23(13):5904-5911. doi: 10.26355/eurrev_201907_18335.
This study aimed to investigate the predictive value of joint detection of serum amyloid A (SAA), plasma procalcitonin (PCT), and whole blood hypersensitive C-reactive protein (hs-CRP) in the diagnosis and efficacy of neonatal septicemia.
A total of 195 cases of neonatal septicemia patients admitted to our hospital from March 2013 to May 2017 were selected as observation group, and 100 healthy newborns in the same period were selected as control group. Before treatment, all newborns were detected with enzyme-linked immunosorbent assay (ELISA) for serum SAA, PCT, and hs-CRP three indicators respectively, and differences between expressions of PCT, HS-CRP, SAA in the serum of children (effective group) who improved after treatment and patients in ineffective group were observed.
Three indexes of SAA, PCT, and hs-CRP in study group were significantly higher than those in control group before treatment, while three indexes of SAA, PCT, and hs-CRP in effective group were significantly lower than those in ineffective group after treatment, with statistical significance (p<0.05). By drawing the ROC curve, it was found that the AUC area, specificity, and sensitivity of joint detection were better than those of the single item detection.
Joint detection of SAA, PCT, and hs-CRP has high diagnostic value in neonatal septicemia and is worthy of clinical application.
本研究旨在探讨血清淀粉样蛋白 A（SAA）、血浆降钙素原（PCT）和全血超敏 C 反应蛋白（hs-CRP）联合检测在新生儿败血症诊断和疗效中的预测价值。
选择 2013 年 3 月至 2017 年 5 月我院收治的 195 例新生儿败血症患者为观察组，同期选择 100 例健康新生儿为对照组。所有新生儿在治疗前均采用酶联免疫吸附试验（ELISA）分别检测血清 SAA、PCT 和 hs-CRP 三个指标，观察治疗后改善的患儿（有效组）与无效组患儿血清 PCT、hs-CRP、SAA 表达的差异。
观察组治疗前 SAA、PCT、hs-CRP 三项指标均明显高于对照组，治疗后有效组 SAA、PCT、hs-CRP 三项指标均明显低于无效组，差异有统计学意义（p<0.05）。绘制 ROC 曲线发现，联合检测的 AUC 面积、特异性和敏感性均优于单项检测。
SAA、PCT、hs-CRP 联合检测对新生儿败血症具有较高的诊断价值，值得临床应用。
