研究 P1NP 和β-CTX 在乳腺癌骨转移患者中的诊断价值及其相关性。

Study on diagnostic value of P1NP and β-CTX in bone metastasis of patients with breast cancer and the correlation between them.

机构信息

Department of General Surgery, The Third People's Hospital of Qingdao, Qingdao, P.R. China.

出版信息

Eur Rev Med Pharmacol Sci. 2019 Jun;23(12):5277-5284. doi: 10.26355/eurrev_201906_18194.

DOI:10.26355/eurrev_201906_18194

PMID:31298379

Abstract

OBJECTIVE

This study aimed to investigate the diagnostic value of the total amino-terminal propeptide of type 1 procollagen (P1NP) and C-terminal telopeptide of β-I collagen (β-CTX) in bone metastasis of patients with breast cancer and the correlation between them.

PATIENTS AND METHODS

The medical records of 73 patients were retrospectively analyzed. These patients with breast cancer were treated in Oncology, General Surgery, and Orthopedic Departments in The Third People's Hospital of Qingdao from March 2014 to April 2017, including 40 patients with bone metastasis (bone metastasis group) and 33 patients with no bone metastasis (non-bone metastasis group). Other 40 healthy people who received physical examination in the same period were selected as the control group. The expression of P1NP and β-CTX in plasma were detected by the Enzyme-linked immunosorbent assay, and the correlation between them was analyzed.

RESULTS

There were significant differences in P1NP and β-CTX concentrations among the three groups (p<0.05). The concentrations of P1NP in the control group and the non-bone metastasis group were significantly lower than that in the bone metastasis group (p<0.05); the concentrations of β-CTX in the control group and the non-bone metastasis group were significantly lower than that in the bone metastasis group (p<0.05). P1NP: AUC=0.852, sensitivity: 72.5%, specificity: 93.9%, CUT OFF=66.44. β-CTX: AUC=0.883, sensitivity: 85.0%, specificity: 84.8%, CUT OFF=69.8. Joint detection: AUC=0.952, sensitivity: 84.8%, specificity: 99.5%, CUT OFF=99.5. The results of the concentrations of P1NP and β-CTX in the bone metastasis group detected by the Pearson correlation analysis showed that their concentrations were positively correlated in the bone metastasis group (r=0.764, p<0.05).

CONCLUSIONS

P1NP and β-CTX in plasma have a high diagnostic value for bone metastasis of breast cancer and have important significance in the diagnosis of bone metastasis and disease monitoring.

摘要

目的

本研究旨在探讨Ⅰ型前胶原氨基端前肽（P1NP）和β-Ⅰ型胶原 C 端肽（β-CTX）在乳腺癌骨转移患者中的诊断价值及其相关性。

方法

回顾性分析 2014 年 3 月至 2017 年 4 月在青岛市第三人民医院肿瘤内科、普外科和骨科治疗的 73 例乳腺癌患者的病历资料，包括 40 例骨转移患者（骨转移组）和 33 例无骨转移患者（非骨转移组）。同期选择 40 例健康体检者作为对照组。采用酶联免疫吸附法检测血浆中 P1NP 和 β-CTX 的表达，并分析两者的相关性。

结果

三组间 P1NP 和 β-CTX 浓度差异有统计学意义（p<0.05）。对照组和非骨转移组 P1NP 浓度明显低于骨转移组（p<0.05）；对照组和非骨转移组 β-CTX 浓度明显低于骨转移组（p<0.05）。P1NP：AUC=0.852，灵敏度：72.5%，特异性：93.9%，CUT OFF=66.44。β-CTX：AUC=0.883，灵敏度：85.0%，特异性：84.8%，CUT OFF=69.8。联合检测：AUC=0.952，灵敏度：84.8%，特异性：99.5%，CUT OFF=99.5。Pearson 相关性分析结果显示，骨转移组中 P1NP 和 β-CTX 浓度呈正相关（r=0.764，p<0.05）。