Magnetic Resonance Center (CERM), University of Florence, and Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine (CIRMMP), via Sacconi 6, Sesto Fiorentino, Italy.
Department of Chemistry, University of Florence, Sesto Fiorentino, Italy.
Chemphyschem. 2019 Sep 3;20(17):2204-2209. doi: 10.1002/cphc.201900587. Epub 2019 Jul 30.
The efficiency of MRI contrast agents depends on the relaxation rate enhancement that they can induce at imaging fields. It is well known that, at these fields, large relaxation rates are obtained by binding of gadolinium(III) ions to large molecules. By the same token, the interaction of the gadolinium(III) complexes with macromolecules that are found in biological tissues can be responsible for an increase of the relaxation rate with respect to the value observed in liquids. We investigate here the relaxation enhancement of gadoteridol (Gd-HP-DO3A) in crosslinked hyaluronic acid, taken as model tissue, using fast field-cycling relaxometry. The analysis of the relaxation profiles as a function of the magnetic fields indicates that a sizable increase in the relaxation rates is due to a modest interaction of the contrast agent with the hydrogel and to the slower mobility of the water molecules outside the first-coordination sphere of the gadolinium(III) ion.
磁共振成像对比剂的效率取决于它们在成像场中可以引起的弛豫率增强。众所周知，在这些场中，通过将镝（III）离子与大分子结合，可以获得较大的弛豫率。同样，在生物组织中发现的大分子与镝（III）配合物的相互作用可能导致弛豫率相对于在液体中观察到的值增加。在这里，我们使用快速场循环弛豫测量法研究了交联透明质酸（作为模型组织）中钆特醇（Gd-HP-DO3A）的弛豫增强。弛豫曲线作为磁场函数的分析表明，弛豫率的显著增加是由于对比剂与水凝胶的适度相互作用以及水的分子在镝（III）离子的第一配位球外的流动性较慢所致。
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