Laboratory of Molecular & Cellular Cardiac Physiology & Patho-physiology, Department of Biology, Ecology & E.S., University of Calabria, 87036 Calabria, Italy.
National Institute for Cardiovascular Research I.N.R.C., 40126 Emilia-Romagna, Italy.
Future Med Chem. 2019 Jun;11(12):1501-1511. doi: 10.4155/fmc-2018-0585. Epub 2019 Jul 12.
The cardiac function critically depends on an adequate myocardial oxygenation and on a correct coronary blood flow. Endothelial, hormonal and extravascular factors work together generating a fine balance between oxygen supply and oxygen utilization through the coronary circulation. Among the regulatory factors that contribute to the coronary tone, increasing attention is paid to the cardiac endocrines, such as chromogranin A, a prohormone for many biologically active peptides, including vasostatin and catestatin. In this review, we will summarize the available evidences about the coronary effects of these molecules, and their putative mechanism of action. Laboratory and clinical data on chromogranin A and its derived fragments will be analyzed in relation to the scenario of the endocrine heart, and of its putative clinical perspectives.
心脏功能严重依赖于心肌氧合和适当的冠状动脉血流。内皮细胞、激素和血管外因素共同作用，通过冠状动脉循环在氧供和氧利用之间产生精细平衡。在调节冠状动脉张力的因素中，人们越来越关注心脏内分泌物，如嗜铬粒蛋白 A，它是许多生物活性肽的前体激素，包括血管抑肽和抑肽。在这篇综述中，我们将总结关于这些分子对冠状动脉的影响及其可能的作用机制的现有证据。将分析与内分泌心脏及其潜在临床观点相关的嗜铬粒蛋白 A 及其衍生片段的实验室和临床数据。
