Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, China.
Department of Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Eur J Neurol. 2019 Nov;26(11):1421-1423. doi: 10.1111/ene.14036. Epub 2019 Aug 12.
This study was conducted to evaluate whether post-thymectomy rapid remission of ocular myasthenia gravis (oMG) is a prognostic indicator of good long-term neurological outcome.
Eighty-four oMG patients who underwent thymectomy at our institute were enrolled. The incidence of 5-year complete stable remission (CSR) was compared between patients with rapid remission of MG status (<1 month after surgery) and those with non-rapid remission.
Kaplan-Meier survival analysis indicated that the incidence of CSR was higher in oMG patients with rapid remission than in those without rapid remission (P < 0.001). Multivariate analysis showed that rapid remission (odds ratio 16.34, 95% confidence interval 3.58-74.60, P < 0.001) is an independent prognostic factor for CSR.
Postoperative rapid remission of MG status predicts a higher likelihood of complete remission in patients with oMG.
本研究旨在评估眼肌型重症肌无力（oMG）术后迅速缓解是否是良好长期神经预后的预测指标。
本研究纳入了在我院接受胸腺切除术的 84 例 oMG 患者。比较了 MG 状态迅速缓解（术后 <1 个月）和非迅速缓解患者 5 年完全稳定缓解（CSR）的发生率。
Kaplan-Meier 生存分析表明，迅速缓解的 oMG 患者 CSR 的发生率高于无迅速缓解的患者（P < 0.001）。多变量分析显示，迅速缓解（优势比 16.34，95%置信区间 3.58-74.60，P < 0.001）是 oMG 患者 CSR 的独立预后因素。
MG 状态术后迅速缓解预示着 oMG 患者完全缓解的可能性更高。
