胸腺瘤切除术后肌无力迅速改善预示着眼肌型重症肌无力患者的长期神经预后良好。
Rapid improvement of muscle weakness post-thymectomy indicates good long-term neurological outcome in patients with ocular myasthenia gravis.
机构信息
Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, China.
Department of Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
出版信息
Eur J Neurol. 2019 Nov;26(11):1421-1423. doi: 10.1111/ene.14036. Epub 2019 Aug 12.
BACKGROUND AND PURPOSE
This study was conducted to evaluate whether post-thymectomy rapid remission of ocular myasthenia gravis (oMG) is a prognostic indicator of good long-term neurological outcome.
METHODS
Eighty-four oMG patients who underwent thymectomy at our institute were enrolled. The incidence of 5-year complete stable remission (CSR) was compared between patients with rapid remission of MG status (<1 month after surgery) and those with non-rapid remission.
RESULTS
Kaplan-Meier survival analysis indicated that the incidence of CSR was higher in oMG patients with rapid remission than in those without rapid remission (P < 0.001). Multivariate analysis showed that rapid remission (odds ratio 16.34, 95% confidence interval 3.58-74.60, P < 0.001) is an independent prognostic factor for CSR.
CONCLUSION
Postoperative rapid remission of MG status predicts a higher likelihood of complete remission in patients with oMG.
背景与目的
本研究旨在评估眼肌型重症肌无力（oMG）术后迅速缓解是否是良好长期神经预后的预测指标。
方法
本研究纳入了在我院接受胸腺切除术的 84 例 oMG 患者。比较了 MG 状态迅速缓解（术后 <1 个月）和非迅速缓解患者 5 年完全稳定缓解（CSR）的发生率。
结果
Kaplan-Meier 生存分析表明，迅速缓解的 oMG 患者 CSR 的发生率高于无迅速缓解的患者（P < 0.001）。多变量分析显示，迅速缓解（优势比 16.34，95%置信区间 3.58-74.60，P < 0.001）是 oMG 患者 CSR 的独立预后因素。
结论
MG 状态术后迅速缓解预示着 oMG 患者完全缓解的可能性更高。
Zotero 插件