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直接观察短程治疗(DOTS)对埃塞俄比亚德布雷塔博尔镇公共卫生机构中结核病患者的治疗效果:回顾性研究

Effectiveness of directly observed treatment short course (DOTS) on treatment of tuberculosis patients in public health facilities of Debre Tabor Town, Ethiopia: retrospective study.

作者信息

Genet Chalachew, Melese Addisu, Worede Abebaw

机构信息

Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

School of Medical Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

BMC Res Notes. 2019 Jul 12;12(1):396. doi: 10.1186/s13104-019-4424-8.

Abstract

OBJECTIVE

The objective of this study is to assess effectiveness of directly observed treatment short course (DOTS) in treatment of tuberculosis (TB) patients in all public health facilities of Debre Tabor town, Ethiopia from January 2016 to December 2017.

RESULT

Among 354 TB patients, 53.1% were males. Furthermore 22.6%, 40.4%, and 37% were smear positive pulmonary, smear negative pulmonary and extra pulmonary TB respectively. Study also revealed that TB-human immunodeficiency virus (HIV) co-infection and overall TB treatment success rate were 18.1% and 90.7% respectively. Regular weigh follow-up, sputum follow-up and HIV status were significantly associated with treatment success with P-value < 0.001, < 0.001 and 0.334 respectively. But TB treatment success weren't associated with sex (P = 8.62), health facility type (P = 0.749) and TB type (P = 0.778). The study also showed that the overall TB treatment success rate was in line with World Health Organization (WHO) target on treatment success rate. Furthermore the study indicated higher TB-HIV co-infection and variations in conducting regular weight and sputum follow-up among HFs.

摘要

目的

本研究的目的是评估2016年1月至2017年12月期间在埃塞俄比亚德布雷塔博尔镇所有公共卫生机构中,直接观察短程治疗(DOTS)对结核病(TB)患者的治疗效果。

结果

在354例结核病患者中,53.1%为男性。此外,分别有22.6%、40.4%和37%为痰涂片阳性肺结核、痰涂片阴性肺结核和肺外结核。研究还显示,结核病与人类免疫缺陷病毒(HIV)合并感染率和总体结核病治疗成功率分别为18.1%和90.7%。定期体重随访、痰涂片随访和HIV感染状况与治疗成功显著相关,P值分别<0.001、<0.001和0.334。但结核病治疗成功与性别(P = 8.62)、医疗机构类型(P = 0.749)和结核类型(P = 0.778)无关。该研究还表明,总体结核病治疗成功率符合世界卫生组织(WHO)的治疗成功率目标。此外,该研究表明结核病与HIV合并感染率较高,且各医疗机构在定期体重和痰涂片随访方面存在差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df0/6625082/54aae071f29f/13104_2019_4424_Fig1_HTML.jpg

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