Laboratoire de Recherche "Santé et Productions Animales", Ecole Nationale Supérieure Vétérinaire d'Alger, Algiers, Algeria.
Laboratoire de Recherche "Santé et Productions Animales", Ecole Nationale Supérieure Vétérinaire d'Alger, Algiers, Algeria; Ecole Supérieure en Sciences de l'Aliment et des Industries Agro-alimentaires, ESSAIA, Algiers, Algeria.
Comp Immunol Microbiol Infect Dis. 2019 Aug;65:128-131. doi: 10.1016/j.cimid.2019.05.014. Epub 2019 May 18.
Sheep pox is a disease of veterinary concern to small ruminant producers and veterinary diagnosticians, because of the associated tangible economic losses. The epidemiological analysis of sheep pox, among vaccinated sheep flock in Algeria from 2007 to 2016, showed that the disease outbreaks occurred every year and across all Algeria region with an average of 44.9 outbreaks per year, these outbreaks correlate with the region climate, the flocks' density and the transhumance practices. The one-year post vaccination antibody kinetics evaluation study of the commercially used vaccine in Algeria demonstrated a mild humoral response, the neutralization index range between 0.73 and 1.22. Therefore, the present study recommends a challenge study, using a virulent local strain, to evaluate the vaccine efficacy. Furthermore, quality control approach for the vaccine production processes is required.
绵羊痘是小反刍动物养殖者和兽医诊断师关注的兽医疾病，因为它会带来相关的经济损失。对 2007 年至 2016 年期间阿尔及利亚接种疫苗羊群中的绵羊痘的流行病学分析表明，该病每年都会暴发，且遍及阿尔及利亚所有地区，每年平均暴发 44.9 次，这些暴发与地区气候、羊群密度和转场放牧有关。对阿尔及利亚市售疫苗接种后一年的抗体动力学评估研究表明，存在温和的体液免疫反应，中和指数在 0.73 至 1.22 之间。因此，本研究建议使用当地毒力株进行挑战研究，以评估疫苗的效力。此外，还需要对疫苗生产过程进行质量控制。
