McMaster University, Hamilton, Ontario, Canada.
J Reprod Immunol. 2019 Sep;134-135:36-39. doi: 10.1016/j.jri.2019.07.003. Epub 2019 Jul 3.
Oral administration of antigen is a potent route for induction of systemic tolerance. Regulatory T cells and TH3 cellsare generated at intestinal mucosal sites. Oral exposure to antigens in seminal plasma has been suggested to be ableto generate 'tolerance' at the materno-fetal interface that may reduce the risk of pre-eclampsia and recurrent miscarriage. Issues relating to assessing the applicability of oral exposure to seminal plasma antigens in recurrentmiscarriage are discussed. Such tolerance could represent an unappreciated confounder in immunotherapy trials.
口服抗原是诱导全身耐受的有效途径。调节性 T 细胞和 TH3 细胞在肠道黏膜部位产生。有人认为，精液中的抗原经口服暴露可在母体-胎儿界面产生“耐受”，从而降低子痫前期和复发性流产的风险。本文讨论了评估口服暴露于精液抗原在复发性流产中的适用性相关问题。这种耐受可能是免疫治疗试验中未被认识的混杂因素。
