Department of Rehabilitation Medicine, University of Minnesota School of Medicine, University of Minnesota Medical School, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, USA.
Pulmonary Division, Department of Medicine, National Jewish Health, Denver, CO, USA.
Spinal Cord. 2019 Dec;57(12):1014-1022. doi: 10.1038/s41393-019-0327-8. Epub 2019 Jul 12.
Cross-sectional study.
To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury.
Veteran Affairs Medical Center.
As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model.
We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r = 0.58).
Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.
横断面研究。
评估临床和人口统计学因素、双膦酸盐使用与慢性脊髓损伤男性循环总骨钙素水平之间的关系。
退伍军人事务医疗中心。
作为一项评估与 SCI 相关健康状况的流行病学研究的一部分，214 名慢性脊髓损伤男性接受了 DXA 扫描，并提供了血液样本以及关于 SCI、药物使用和骨折史的信息。采用一般线性模型评估骨钙素的临床/人口统计学因素，如果有显著差异，则纳入多变量模型。
我们发现，瘦体重每增加 1 公斤，总骨钙素水平增加 1.0ng/ml（p=0.05），C 端肽水平每增加 1ng/ml，总骨钙素水平增加 4.53ng/ml（p<0.0001）。与饮酒者相比，不饮酒者的骨钙素水平更高（15.49ng/ml 比 18.58ng/ml，p<0.0002），糖尿病患者比非糖尿病患者低（15.23ng/ml 比 18.92ng/ml，p=0.0001），双膦酸盐使用者比非使用者低（15.50ng/ml 比 18.58ng/ml，p<0.03）。年龄与骨钙素之间的关联不显著（p=0.06）。该模型解释了 ln 骨钙素水平变化的 58%（模型 p<0.0001，r=0.58）。
在慢性脊髓损伤男性中，总骨钙素水平因健康习惯、身体成分、合并疾病和双膦酸盐使用而有所不同。
