Department of Physiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias, 11527, Athens, Greece.
Assisted Conception Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Vasilissis Sofias str., 11528, Athens, Greece.
Front Med. 2019 Dec;13(6):627-638. doi: 10.1007/s11684-019-0697-5. Epub 2019 Jul 12.
Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is associated with futile attempts, IVF overuse, and dead ends in management. Cutting edge research on animal models introduced this concept, along with the development of artificial organs with the aim to mimic the respective physiological functions in reproduction. Extrapolation on clinical application leads to the future use of infertility management in humans. To date, the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical trials. The application of these artificial organs could provide a solution to infertility cases with no other options. This manuscript presents an overview on the current status, future prospects, and considerations on the potential clinical application of artificial ovary, uterus, and gametes in humans. This paper presents how the IVF practice landscape may be shaped and challenged in the future, along with the subsequent concerns in assisted reproductive treatments.
辅助生殖提供了广泛的治疗方法和策略，用于解决不孕不育问题。然而，不明原因不孕、先天性疾病和其他复杂病例的不同不孕患者群体在体外受精（IVF）实践中构成了挑战。这些特殊的患者群体与无效尝试、IVF 过度使用以及管理上的死胡同有关。动物模型的前沿研究提出了这个概念，同时还开发了人工器官，旨在模拟生殖中的相应生理功能。临床应用的推断导致未来在人类中使用不孕不育管理。迄今为止，由于在临床试验之前还需要进一步的动物模型研究，因此在人类中成功应用人工生殖器官是不可行的。这些人工器官的应用可以为没有其他选择的不孕病例提供解决方案。本文概述了人工卵巢、子宫和配子在人类中的当前状况、未来前景和潜在临床应用的考虑因素。本文探讨了未来 IVF 实践领域可能会如何受到影响和挑战，以及辅助生殖治疗中随之而来的担忧。
