Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, 3401 North Broad Street, Philadelphia, PA, 19140, USA.
Dig Dis Sci. 2019 Dec;64(12):3451-3462. doi: 10.1007/s10620-019-05723-2. Epub 2019 Jul 12.
Caregiver burden can be significant in chronic gastrointestinal diseases. No studies have been performed to evaluate caregiver burden in gastroparesis or gastroesophageal reflux disease (GERD).
(1) Assess the caregiver burden in gastroparesis and GERD patients and healthy volunteers (HVs); (2) correlate the caregiver burden of these patients to the severity of patients' symptoms, healthcare utilization, and work productivity of the patients and the caregivers.
Patients with gastroparesis and GERD, seen between June 2018 and November 2018, completed Patient Assessment of Gastrointestinal Symptoms, Work Productivity and Activity Impairment (WPAI) and healthcare utilization questionnaires. The caregivers of these patients completed Zarit Burden Interview (ZBI) and WPAI questionnaire. HVs and their potential caregivers also completed these questionnaires.
Forty-seven patients (gastroparesis = 31, GERD = 17), 12 HVs, and their caregivers completed questionnaires. Caregivers of gastroparesis patients reported high burden on ZBI (27.7 ± 2.9), greater than the caregivers of GERD (14.9 ± 2.5) and HVs (5.5 ± 1.6, p < 0.01). Among all patients, the caregiver burden had a strong correlation with patients' Gastroparesis Cardinal Symptom Index (GCSI) total score (r = 0.63, p < 0.01) and moderate correlations with the number of patients' physician office visits (r = 0.46, p < 0.01) and the number of work hours missed by caregivers due to patients' symptoms (r = 0.36, p = 0.04). Using multivariable regression, both presence of gastroparesis and other comorbidities significantly predicted caregiver burden, F(2, 33) = 15.94, p < 0.0001, R = 0.491.
Caregivers of gastroparesis patients have high caregiver burden that strongly correlates with patients' GCSI total score. Interventions to reduce symptom severity of Gp patients may reduce the caregiver burden.
在慢性胃肠道疾病中，照顾者的负担可能很大。目前尚未有研究评估胃轻瘫或胃食管反流病（GERD）患者的照顾者负担。
（1）评估胃轻瘫和 GERD 患者及健康志愿者（HV）的照顾者负担；（2）将这些患者的照顾者负担与患者症状的严重程度、医疗保健的使用以及患者和照顾者的工作生产力相关联。
2018 年 6 月至 11 月期间就诊的胃轻瘫和 GERD 患者完成了胃肠道症状评估、工作生产力和活动障碍（WPAI）以及医疗保健使用问卷。这些患者的照顾者完成了 Zarit 负担访谈（ZBI）和 WPAI 问卷。HV 及其潜在照顾者也完成了这些问卷。
共 47 例患者（胃轻瘫=31 例，GERD=17 例）、12 例 HV 和他们的照顾者完成了问卷。胃轻瘫患者的照顾者报告 ZBI 评分较高（27.7±2.9），高于 GERD 患者的照顾者（14.9±2.5）和 HV 的照顾者（5.5±1.6，p<0.01）。在所有患者中，照顾者负担与患者的胃轻瘫关键症状指数（GCSI）总分呈强相关（r=0.63，p<0.01），与患者就诊次数（r=0.46，p<0.01）和照顾者因患者症状而错过的工作小时数（r=0.36，p=0.04）呈中度相关。使用多元回归分析，胃轻瘫的存在和其他合并症均显著预测了照顾者负担，F（2，33）=15.94，p<0.0001，R=0.491。
胃轻瘫患者的照顾者负担很重，与患者的 GCSI 总分密切相关。干预胃轻瘫患者的症状严重程度可能会减轻照顾者的负担。
